627872-67-7

Upstream product

• 27916-67-2 2,3,4-tris(benzyloxy)benzaldehyde 
• 100-39-0 benzyl bromide 
• 2144-08-3 2,3,4-trihydroxybenzylaldehyde 

Downstream Products

• 400008-17-5 3,4-bis-benzyloxy-2-(tert-butyl-dimethyl-silanyloxy)-benzaldehyde 
• 627872-68-8 3,4-bis(benzyloxy)-5-bromo-2-hydroxybenzaldehyde 
• 1610522-99-0 7,8-bis(benzyloxy)-3-(piperazine-1-carbonyl)-2H-chromen-2-one hydrochloride 
• 1610523-40-4 tert-butyl 4-(7,8-bis(benzyloxy)-2-oxo-2H-chromene-3-carbonyl)piperazine-1-carboxylate 
• 1610523-00-6 7,8-bis(benzyloxy)-3-(4-(7,8-bis(methoxymethoxy)-2-oxo-2Hchromene-3-carbonyl)piperazine-1-carbonyl)-2H-chromen-2-one 
• 1610522-98-9 7,8-bis(benzyloxy)-2-oxo-2H-chromene-3-carboxylic acid 
• 400008-18-6 (4-benzyloxy-2,6-dimethoxy-phenyl)-[3,4-bis-benzyloxy-2-(tert-butyl-dimethyl-silanyloxy)-phenyl]-methanol 
• 400008-20-0 (4-benzyloxy-2,6-dimethoxy-phenyl)-(3,4-bis-benzyloxy-2-hydroxy-phenyl)-methanone 
• 400008-19-7 2,3-bis-benzyloxy-6-[(4-benzyloxy-2,6-dimethoxy-phenyl)-hydroxy-methyl]-phenol 
• 42833-98-7 3,5,6-tris-benzyloxy-1-methoxy-xanthen-9-one 
• 697302-73-1 [2-({[7,8-bis(benzyloxy)-2,2-dimethyl-4H-1,3-benzodioxin-6-yl]oxy}methoxy)ethyl](trimethyl)silane 
• 627872-53-1 7,8-bis(benzyloxy)-2,2-dimethyl-4H-1,3-benzodioxin-6-ol 
• 627872-70-2 7,8-bis(benzyloxy)-6-methoxy-2,2-dimethyl-4H-1,3-benzodioxine 
• 627872-69-9 7,8-bis(benzyloxy)-6-bromo-2,2-dimethyl-4H-1,3-benzodioxine 

Relevant academic research and scientific papers

Synthetic method for dihydrostilbenes and anti-inflammatory compounds containing thereof

The present invention aims to provide an effective anti-inflammatory agent without side effects. The present inventors have invented a method for efficiently synthesizing dihydrostilbene and derivatives (compounds 1 to 5) from starting materials at a high yield. In addition, the anti-inflammatory effects were evaluated in LPS-induced RAW-264.7 macrophages. The compounds of dihydrostilbene do not exhibit cytotoxicity and are shown to weakly or well inhibit nitric oxide production induced by LPS at the concentration of 10 andmu;M.COPYRIGHT KIPO 2018

Dihydrostilbenes and diarylpropanes: Synthesis and in vitro pharmacological evaluation as potent nitric oxide production inhibition agents

An efficient synthesis of dihydrostilbenes (1–5) and diarylpropanes (6–10) is achieved from the commercially available starting materials and Wittig-Horner reaction, Claisen–Schmidt condensation and hydrogenation as key steps. Later, their nitric oxide (NO) production inhibition effects were evaluated in lipopolysaccharide (LPS)-induced RAW-264.7 macrophages as an indicator of anti-inflammatory activity. All the tested compounds significantly decreased NO production in a concentration-dependent manner except compounds 2, 6 and 8 and did not show notable cytotoxicity except compound 1. Two compounds i.e., compound 9 (hindsiipropane B) (100%; IC50?=?1.84?μM) possessed the most potent NO inhibitory activity which was even stronger than the positive control, L-NMMA (90.1%; IC50?=?2.73?μM) followed by compound 4 (75.5%; IC50?=?2.98?μM) at 10?μM concentration and this finding was also further correlated by suppressed expression of LPS stimulated inducible NO synthase. Our study revealed that compound 9, a 1,3-diarylpropane scaffold with 3″,4″-dimethoxyphenyl and 3′,4′-dihydroxy-2′-methoxyphenyl motifs could be considered as potential compound or lead compound for further development of NO production-targeted anti-inflammatory agents.

Design and synthesis of 3,3′-biscoumarin-based c-Met inhibitors

A library of biscoumarin-based c-Met inhibitors was synthesized, based on optimization of 3,3′-biscoumarin hit 3, which was identified as a non-ATP competitive inhibitor of c-Met from a diverse library of coumarin derivatives. Among these compounds, 38 and 40 not only showed potent enzyme activities with IC50 values of 107 nM and 30 nM, respectively, but also inhibited c-Met phosphorylation in BaF3/TPR-Met and EBC-1 cells. This journal is the Partner Organisations 2014.

Biomimetically Inspired Total Synthesis and Structure Activity Relationships of 1-O-Methyllateriflorone. 6π Electrocyclizations in Organic Synthesis

The total synthesis of 1-O-methyllateriflorone (2) is described. The construction of the cage-like domain of the molecule involved a biomimetic Claisen/Diels-Alder cascade, whereas the novel spiroxalactone framework was generated by an intramolecular Mich

Total synthesis of 1-O-methyllateriflorone

The unique spiroxalactone framework of lateriflorone (1) consists of a prenylated dihydrobenzoquinone moiety and a trioxatetracyclotetradecane system. A tandem Claisen rearrangement/Diels-Alder cascade was the key step in the synthesis of the complex tetr

"Biomimetic" cascade reactions in organic synthesis: Construction of 4-oxatricyclo-[4.3.1.0]decan-2-one systems and total synthesis of 1-O-methylforbesione via tandem claisen rearrangement/diels-alder reactions

A further demonstration of the value of "biomimetically" inspired synthetic strategies toward natural products is provided by the title reactions that were developed for the construction of 4-oxatricyclo[4.3.1.0]decan-2-one systems from prochiral aromatic