Trifluoro-methanesulfonic acid 5-[3-{2-[1-(tert-butyl-dimethyl-silanyloxy)-prop-2-ynyl]-phenyl}-prop-2-yn-(Z)-ylidene]-cyclopent-1-enyl ester

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Chemical Name:Trifluoro-methanesulfonic acid 5-[3-{2-[1-(tert-butyl-dimethyl-silanyloxy)-prop-2-ynyl]-phenyl}-prop-2-yn-(Z)-ylidene]-cyclopent-1-enyl ester
CAS No.:155720-54-0
Molecular Formula:C₂₄H₂₇F₃O₄SSi
Molecular Weight:496.623
Hs Code.:

Synonyms:Trifluoro-methanesulfonic acid 5-[3-{2-[1-(tert-butyl-dimethyl-silanyloxy)-prop-2-ynyl]-phenyl}-prop-2-yn-(Z)-ylidene]-cyclopent-1-enyl ester

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Chemical Property of Trifluoro-methanesulfonic acid 5-[3-{2-[1-(tert-butyl-dimethyl-silanyloxy)-prop-2-ynyl]-phenyl}-prop-2-yn-(Z)-ylidene]-cyclopent-1-enyl ester

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Technology Process of Trifluoro-methanesulfonic acid 5-[3-{2-[1-(tert-butyl-dimethyl-silanyloxy)-prop-2-ynyl]-phenyl}-prop-2-yn-(Z)-ylidene]-cyclopent-1-enyl ester

There total 6 articles about Trifluoro-methanesulfonic acid 5-[3-{2-[1-(tert-butyl-dimethyl-silanyloxy)-prop-2-ynyl]-phenyl}-prop-2-yn-(Z)-ylidene]-cyclopent-1-enyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 155720-53-9
(Z)-<5-<3-<2-<1-Hydroxy-2-propynyl>phenyl>-2-propynylidene>-1-cyclopenten-1-yl> trifluoromethanesulfonate

: 155720-54-0
Trifluoro-methanesulfonic acid 5-[3-{2-[1-(tert-butyl-dimethyl-silanyloxy)-prop-2-ynyl]-phenyl}-prop-2-yn-(Z)-ylidene]-cyclopent-1-enyl ester

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; for 4h;

Reference yield:

: 38846-64-9
2-ethynylbenzaldehyde

: 155720-54-0
Trifluoro-methanesulfonic acid 5-[3-{2-[1-(tert-butyl-dimethyl-silanyloxy)-prop-2-ynyl]-phenyl}-prop-2-yn-(Z)-ylidene]-cyclopent-1-enyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 91 percent / n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C

2: 47 percent / i-Pr₂NH / Pd(PPh₃)2Cl₂, CuI / tetrahydrofuran / 1.) 0 deg C, 30 min, 2.) 20 deg C, 90 min

3: 75 percent / CsF / methanol / 30 h / 20 °C

4: 83 percent / imidazole / dimethylformamide / 4 h / 20 °C

With 1H-imidazole; n-butyllithium; diisopropylamine; cesium fluoride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; methanol; hexane; N,N-dimethyl-formamide;

Reference yield:

: 77123-58-1
2-[2-(trimethylsilyl)ethynyl]benzaldehyde

: 155720-54-0
Trifluoro-methanesulfonic acid 5-[3-{2-[1-(tert-butyl-dimethyl-silanyloxy)-prop-2-ynyl]-phenyl}-prop-2-yn-(Z)-ylidene]-cyclopent-1-enyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 95 percent / KF / methanol / 3 h / 20 °C

2: 91 percent / n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C

3: 47 percent / i-Pr₂NH / Pd(PPh₃)2Cl₂, CuI / tetrahydrofuran / 1.) 0 deg C, 30 min, 2.) 20 deg C, 90 min

4: 75 percent / CsF / methanol / 30 h / 20 °C

5: 83 percent / imidazole / dimethylformamide / 4 h / 20 °C

With 1H-imidazole; potassium fluoride; n-butyllithium; diisopropylamine; cesium fluoride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; methanol; hexane; N,N-dimethyl-formamide;