(S)-3-((R)-4-Benzyl-2-oxo-oxazolidine-3-carbonyl)-hex-5-enoic acid butylamide

Base Information

Chemical Name:(S)-3-((R)-4-Benzyl-2-oxo-oxazolidine-3-carbonyl)-hex-5-enoic acid butylamide
CAS No.:851518-65-5
Molecular Formula:C₂₁H₂₈N₂O₄
Molecular Weight:372.464
Hs Code.:

Synonyms:(S)-3-((R)-4-Benzyl-2-oxo-oxazolidine-3-carbonyl)-hex-5-enoic acid butylamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-3-((R)-4-Benzyl-2-oxo-oxazolidine-3-carbonyl)-hex-5-enoic acid butylamide

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Technology Process of (S)-3-((R)-4-Benzyl-2-oxo-oxazolidine-3-carbonyl)-hex-5-enoic acid butylamide

There total 3 articles about (S)-3-((R)-4-Benzyl-2-oxo-oxazolidine-3-carbonyl)-hex-5-enoic acid butylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 109-73-9,85404-21-3
N-butylamine

: 851518-40-6
(S)-3-((R)-4-benzyl-2-oxooxazolidine-3-carbonyl)hex-5-enoic acid

: 851518-65-5
(S)-3-((R)-4-Benzyl-2-oxo-oxazolidine-3-carbonyl)-hex-5-enoic acid butylamide

Guidance literature:: With dmap; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 3h;
DOI:10.1021/ja048170p

Reference yield:

: 155399-10-3
(4R)-3-(4-pentenoyl)-4-(phenylmethyl)-1,3-oxazolidin-2-one

: 851518-65-5
(S)-3-((R)-4-Benzyl-2-oxo-oxazolidine-3-carbonyl)-hex-5-enoic acid butylamide

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / LDA / tetrahydrofuran / 2.33 h / -78 °C

2: 87 percent / TFA; Et₃SiH / CH₂Cl₂ / 2 h / 20 °C

3: 82 percent / DCC; DMAP; HOBt / CH₂Cl₂ / 3 h / 20 °C

With triethylsilane; dmap; benzotriazol-1-ol; dicyclohexyl-carbodiimide; trifluoroacetic acid; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja048170p

Reference yield:

: 851518-35-9
(S)-tert-butyl 3-((R)-4-benzyl-2-oxooxazolidine-3-carbonyl)hex-5-enoate

: 851518-65-5
(S)-3-((R)-4-Benzyl-2-oxo-oxazolidine-3-carbonyl)-hex-5-enoic acid butylamide

Guidance literature:: Multi-step reaction with 2 steps

1: 87 percent / TFA; Et₃SiH / CH₂Cl₂ / 2 h / 20 °C

2: 82 percent / DCC; DMAP; HOBt / CH₂Cl₂ / 3 h / 20 °C

With triethylsilane; dmap; benzotriazol-1-ol; dicyclohexyl-carbodiimide; trifluoroacetic acid; In dichloromethane;
DOI:10.1021/ja048170p