(1R,2E)-2-(3-benzyloxypropylidene)-1-(2-chlorophenyl)cyclohexyl isocyanate

Base Information

• Chemical Name: (1R,2E)-2-(3-benzyloxypropylidene)-1-(2-chlorophenyl)cyclohexyl isocyanate
• CAS No.: 1207986-35-3
• Molecular Formula: C₂₃H₂₄ClNO₂
• Molecular Weight: 381.902
• Mol file: 1207986-35-3.mol

Synonyms:(1R,2E)-2-(3-benzyloxypropylidene)-1-(2-chlorophenyl)cyclohexyl isocyanate

Chemical Property of (1R,2E)-2-(3-benzyloxypropylidene)-1-(2-chlorophenyl)cyclohexyl isocyanate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,2E)-2-(3-benzyloxypropylidene)-1-(2-chlorophenyl)cyclohexyl isocyanate

There total 1 articles about (1R,2E)-2-(3-benzyloxypropylidene)-1-(2-chlorophenyl)cyclohexyl isocyanate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-3-benzyloxy-1-[2-(2-chlorophenyl)-1-cyclohexenyl]propyl carbamate (1207986-33-1) → (1S,2E)-2-(3-benzyloxypropylidene)-1-(2-chlorophenyl)cyclohexyl isocyanate + (1R,2E)-2-(3-benzyloxypropylidene)-1-(2-chlorophenyl)cyclohexyl isocyanate (1207986-35-3)

Guidance literature:

With carbon tetrabromide; triethylamine; triphenylphosphine; In dichloromethane; at 0 ℃; for 0.5h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;

DOI:10.1246/bcsj.82.1528

Reference yield: 87.0%

(1R,2E)-2-(3-benzyloxypropylidene)-1-(2-chlorophenyl)cyclohexyl isocyanate (1207986-35-3) → (1R,2E)-2-(3-benzyloxypropylidene)-1-(2-chlorophenyl)-1-methylaminocyclohexane (1207986-37-5)

Guidance literature:

(1R,2E)-2-(3-benzyloxypropylidene)-1-(2-chlorophenyl)cyclohexyl isocyanate; With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; Inert atmosphere; Reflux;

With sodium hydroxide; In tetrahydrofuran; at 90 ℃; for 1h; Inert atmosphere;

DOI:10.1246/bcsj.82.1528

upstream raw materials:

(S)-3-benzyloxy-1-[2-(2-chlorophenyl)-1-cyclohexenyl]propyl carbamate

Downstream raw materials:

(1R,2E)-2-(3-benzyloxypropylidene)-1-(2-chlorophenyl)-1-methylaminocyclohexane