(3S)-3-[(2S)-1-(tert-butyloxycarbonyl)tetrahydro-1H-2-pyrrolyl]carboxamido-4-phenylbutanoic acid methyl ester

Base Information

• Chemical Name: (3S)-3-[(2S)-1-(tert-butyloxycarbonyl)tetrahydro-1H-2-pyrrolyl]carboxamido-4-phenylbutanoic acid methyl ester
• CAS No.: 1200953-79-2
• Molecular Formula: C₂₁H₃₀N₂O₅
• Molecular Weight: 390.48
• Mol file: 1200953-79-2.mol

Synonyms:(3S)-3-[(2S)-1-(tert-butyloxycarbonyl)tetrahydro-1H-2-pyrrolyl]carboxamido-4-phenylbutanoic acid methyl ester

Chemical Property of (3S)-3-[(2S)-1-(tert-butyloxycarbonyl)tetrahydro-1H-2-pyrrolyl]carboxamido-4-phenylbutanoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of (3S)-3-[(2S)-1-(tert-butyloxycarbonyl)tetrahydro-1H-2-pyrrolyl]carboxamido-4-phenylbutanoic acid methyl ester

There total 1 articles about (3S)-3-[(2S)-1-(tert-butyloxycarbonyl)tetrahydro-1H-2-pyrrolyl]carboxamido-4-phenylbutanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

1-(tert-butoxycarbonyl)-L-proline (15761-39-4,59433-50-0) + homo-β-phenylalanine methyl ester (68978-89-2) → (3S)-3-[(2S)-1-(tert-butyloxycarbonyl)tetrahydro-1H-2-pyrrolyl]carboxamido-4-phenylbutanoic acid methyl ester (1200953-79-2)

Guidance literature:

1-(tert-butoxycarbonyl)-L-proline; With benzotriazol-1-ol; In dichloromethane; at 0 ℃;

homo-β-phenylalanine methyl ester; With dicyclohexyl-carbodiimide; In dichloromethane; at 0 ℃;

DOI:10.1021/jo902106r

Reference yield: 90.0%

(3S)-3-[(2S)-1-(tert-butyloxycarbonyl)tetrahydro-1H-2-pyrrolyl]carboxamido-4-phenylbutanoic acid methyl ester (1200953-79-2) → (3S)-4-phenyl-3-[(2S)-tetrahydro-1H-2-pyrrolylcarboxamido]butanoic acid methyl ester (1200953-41-8)

Guidance literature:

(3S)-3-[(2S)-1-(tert-butyloxycarbonyl)tetrahydro-1H-2-pyrrolyl]carboxamido-4-phenylbutanoic acid methyl ester; With formic acid; at 0 - 20 ℃;

With ammonia; water; at 0 ℃;

DOI:10.1021/jo902106r

upstream raw materials:

1-(tert-butoxycarbonyl)-L-proline

homo-β-phenylalanine methyl ester

Downstream raw materials:

(3S)-4-phenyl-3-[(2S)-tetrahydro-1H-2-pyrrolylcarboxamido]butanoic acid methyl ester