homo-β-phenylalanine methyl ester

Base Information

• Chemical Name: homo-β-phenylalanine methyl ester
• CAS No.: 68978-89-2
• Molecular Formula: C₁₁H₁₅NO₂
• Molecular Weight: 193.246
• Mol file: 68978-89-2.mol

Synonyms:homo-β-phenylalanine methyl ester

Chemical Property of homo-β-phenylalanine methyl ester

Chemical Property:

• Boiling Point: 305.0±35.0 °C(Predicted)
• Density: 1.077±0.06 g/cm3(Predicted)

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of homo-β-phenylalanine methyl ester

There total 17 articles about homo-β-phenylalanine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

→ homo-β-phenylalanine methyl ester (68978-89-2)

Guidance literature:

Reference yield: 95.6%

methyl (3S)-3-{[(tert-butoxy)carbonyl]amino}-4-phenylbutanoate (60398-42-7,142854-48-6) → homo-β-phenylalanine methyl ester (68978-89-2)

Guidance literature:

With sodium hydroxide; trifluoroacetic acid; In dichloromethane;

Reference yield: 78.0%

methanol (67-56-1) + (S)-3-tert-butoxycarbonylamino-4-phenylbutanoic acid (51871-62-6) → homo-β-phenylalanine methyl ester (68978-89-2)

Guidance literature:

With thionyl chloride;

DOI:10.1021/ja9058074

upstream raw materials:

methyl N-(benzyloxycarbonyl)-(3S)-3-amino-4-phenylbutanoate

methyl (3S)-3-{[(tert-butoxy)carbonyl]amino}-4-phenylbutanoate

diazomethane

(S)-3-amino-4-phenylbutanoic acid hydrochloride

Downstream raw materials:

C₂₅H₃₃N₃O₅

(S)-methyl 3-((S)-3-(tert-butoxycarbonylamino)-4-phenylbutanamido)-4-phenyl butanoate

(3S)-3-[(2S)-1-(tert-butyloxycarbonyl)tetrahydro-1H-2-pyrrolyl]carboxamido-4-phenylbutanoic acid methyl ester

cyclo(β³-HTrp-β³-HPhe-β³-HThr(OBn)-β³-HLys(N^ε-2-Cl-Z))

Refernces

• 1、 Mocquet, Clemence,Salauen, Arnaud,Claudon, Paul,Le Grel, Barbara,Potel, Michel,Guichard, Gilles,Jamart-Gregoire, Brigitte,Le Grel, Philippe. "Aza-β3-cyclopeptides: A new way of controlling nitrogen chirality". supporting information; experimental part. p. 14521 - 14525. Retrieved 2010/02/28.
• 2、 Li, Xiang-Guo,Kanerva, Liisa T.. "Lipase-involved strategy to the enantiomers of 4-benzyl-β-lactam as a key intermediate in the preparation of β-phenylalanine derivatives". . p. 197 - 205. Retrieved 2007/10/03.