1-[(tert-butyldiphenylsilyl)methyl]-1,2,3,6-tetrahydro-4-methyl-2-pyridinecarbonitrile

Base Information

Chemical Name:1-[(tert-butyldiphenylsilyl)methyl]-1,2,3,6-tetrahydro-4-methyl-2-pyridinecarbonitrile
CAS No.:297170-24-2
Molecular Formula:C₂₄H₃₀N₂Si
Molecular Weight:374.601
Hs Code.:

Synonyms:1-[(tert-butyldiphenylsilyl)methyl]-1,2,3,6-tetrahydro-4-methyl-2-pyridinecarbonitrile

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-[(tert-butyldiphenylsilyl)methyl]-1,2,3,6-tetrahydro-4-methyl-2-pyridinecarbonitrile

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Technology Process of 1-[(tert-butyldiphenylsilyl)methyl]-1,2,3,6-tetrahydro-4-methyl-2-pyridinecarbonitrile

There total 5 articles about 1-[(tert-butyldiphenylsilyl)methyl]-1,2,3,6-tetrahydro-4-methyl-2-pyridinecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 143-33-9,25596-52-5
sodium cyanide

: 1-[(tert-butyldiphenylsilyl)methyl]-4-methylpyridinium trifluoromethanesulfonate

: 297170-24-2
1-[(tert-butyldiphenylsilyl)methyl]-1,2,3,6-tetrahydro-4-methyl-2-pyridinecarbonitrile

Guidance literature:: With sodium tetrahydroborate; In methanol; diethyl ether; water; at 20 ℃; for 0.5h;
DOI:10.1080/00397910008086931

Reference yield:

: 108-89-4
picoline

: 297170-24-2
1-[(tert-butyldiphenylsilyl)methyl]-1,2,3,6-tetrahydro-4-methyl-2-pyridinecarbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / acetonitrile / 2.5 h / 20 °C

2: 50 percent / NaBH₄ / methanol; H₂O; diethyl ether / 0.5 h / 20 °C

With sodium tetrahydroborate; In methanol; diethyl ether; water; acetonitrile; 1: Alkylation / 2: Reduction;
DOI:10.1080/00397910008086931

Reference yield:

: 144314-38-5
(tert-butyldiphenylsilyl)methanol

: 297170-24-2
1-[(tert-butyldiphenylsilyl)methyl]-1,2,3,6-tetrahydro-4-methyl-2-pyridinecarbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: 93 percent / CH₂Cl₂ / 3 h / 20 °C

2: 85 percent / acetonitrile / 2.5 h / 20 °C

3: 50 percent / NaBH₄ / methanol; H₂O; diethyl ether / 0.5 h / 20 °C

With sodium tetrahydroborate; In methanol; diethyl ether; dichloromethane; water; acetonitrile; 1: Esterification / 2: Alkylation / 3: Reduction;
DOI:10.1080/00397910008086931