DL-serine hydrochloride

Base Information

• Chemical Name: DL-serine hydrochloride
• CAS No.: 51221-50-2
• Molecular Formula: C₃H₇NO₃*ClH
• Molecular Weight: 141.554
• Mol file: 51221-50-2.mol

Synonyms:DL-serine hydrochloride

Chemical Property of DL-serine hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of DL-serine hydrochloride

There total 5 articles about DL-serine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

N-(t-butyloxycarbonyl)-O-(t-butyl)-L-Serine (13734-38-8,20887-86-9) → D,L-serine hydrochloride (16428-75-4,51221-50-2)

Guidance literature:

With sulfuric acid; sodium chloride; In neat (no solvent); at 20 ℃; for 16h; Sealed tube; Inert atmosphere;

DOI:10.1039/d1ob00728a

Reference yield: 95.0%

L-serin (56-45-1,83245-15-2) → D,L-serine hydrochloride (16428-75-4,51221-50-2)

Guidance literature:

With thionyl chloride; In methanol; at 70 ℃; for 4.9h; Time;

Reference yield: 32.0%

methyl (3S)-3-(m-chlorobenzoyloxy)-N-trifluoroacetylalaninate (161771-71-7) → D,L-serine hydrochloride (16428-75-4,51221-50-2)

Guidance literature:

With hydrogenchloride; In water; for 2h; Heating;

DOI:10.1039/P19950000157

upstream raw materials:

methyl (3S)-3-(m-chlorobenzoyloxy)-N-trifluoroacetylalaninate

L-serin

versicoloritide C

N-(t-butyloxycarbonyl)-O-(t-butyl)-L-Serine

Downstream raw materials:

β-chloro-L-alanine hydrochloride

methyl 2-((5-chloro-2-[(2-methylpropyl)oxy]phenyl)methyl)-4,5-dihydro-1,3-oxazole-4-carboxylate

2-oxo-propionic acid

rac-Ala-OH

Refernces

• 1、 -. "L-serine linked dihydroartemisinin-fluoroquinolone conjugate and intermediate thereof, preparation methods of L-serine linked dihydroartemisinin-fluoroquinolone conjugate and intermediate thereof, and uses of L-serine linked dihydroartemisinin-fluoroquinolone conjugate". Paragraph 0121-0126. . Retrieved 2019/11/29.
• 2、 Burakowski, Andrzej,Gliński, Jacek. "Hydration of amino acids from ultrasonic measurements". experimental part. p. 12157 - 12161. Retrieved 2011/01/11.