(1R,2S,3S,5S)-3-[[(4-methoxyphenyl)methyl]thio]-8-methyl-8-azabicyclo[3.2.1]octane-2-carbothioic acid S-[(4-methoxyphenyl)methyl] ester

Base Information

Chemical Name:(1R,2S,3S,5S)-3-[[(4-methoxyphenyl)methyl]thio]-8-methyl-8-azabicyclo[3.2.1]octane-2-carbothioic acid S-[(4-methoxyphenyl)methyl] ester
CAS No.:426813-54-9
Molecular Formula:C₂₅H₃₁NO₃S₂
Molecular Weight:457.658
Hs Code.:

Synonyms:(1R,2S,3S,5S)-3-[[(4-methoxyphenyl)methyl]thio]-8-methyl-8-azabicyclo[3.2.1]octane-2-carbothioic acid S-[(4-methoxyphenyl)methyl] ester

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Chemical Property of (1R,2S,3S,5S)-3-[[(4-methoxyphenyl)methyl]thio]-8-methyl-8-azabicyclo[3.2.1]octane-2-carbothioic acid S-[(4-methoxyphenyl)methyl] ester

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Technology Process of (1R,2S,3S,5S)-3-[[(4-methoxyphenyl)methyl]thio]-8-methyl-8-azabicyclo[3.2.1]octane-2-carbothioic acid S-[(4-methoxyphenyl)methyl] ester

There total 3 articles about (1R,2S,3S,5S)-3-[[(4-methoxyphenyl)methyl]thio]-8-methyl-8-azabicyclo[3.2.1]octane-2-carbothioic acid S-[(4-methoxyphenyl)methyl] ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.8%

: 6258-60-2
p-methoxybenzylmercaptan

: 50373-10-9
methyl ecgonidine

: 8-methyl-8-azabicyclo[3.2.1]oct-2-ene-2-carbothioic acid S-[(4-methoxyphenyl)methyl] ester

: 426813-54-9
(1R,2S,3S,5S)-3-[[(4-methoxyphenyl)methyl]thio]-8-methyl-8-azabicyclo[3.2.1]octane-2-carbothioic acid S-[(4-methoxyphenyl)methyl] ester

: 426813-52-7
(1R,2R,3S,5S)-3-[[(4-methoxyphenyl)methyl]thio]-8-methyl-8-azabicyclo[3.2.1]octane-2-carbothioic acid S-[(4-methoxyphenyl)methyl] ester

Guidance literature:: p-methoxybenzylmercaptan; With ethylmagnesium bromide; In tetrahydrofuran; at 20 ℃;

methyl ecgonidine; In tetrahydrofuran; at 20 ℃; for 14h; Further stages.;
DOI:10.1021/ja012376y

Reference yield: 20.7%

: 6258-60-2
p-methoxybenzylmercaptan

: 50373-10-9
methyl ecgonidine

: 426813-54-9
(1R,2S,3S,5S)-3-[[(4-methoxyphenyl)methyl]thio]-8-methyl-8-azabicyclo[3.2.1]octane-2-carbothioic acid S-[(4-methoxyphenyl)methyl] ester

: 426813-52-7
(1R,2R,3S,5S)-3-[[(4-methoxyphenyl)methyl]thio]-8-methyl-8-azabicyclo[3.2.1]octane-2-carbothioic acid S-[(4-methoxyphenyl)methyl] ester

Guidance literature:: p-methoxybenzylmercaptan; With ethylmagnesium bromide; In tetrahydrofuran; at 20 ℃;

methyl ecgonidine; In tetrahydrofuran; at 20 ℃; for 70h; Further stages.;
DOI:10.1021/ja012376y

Reference yield:

: 53-21-4
(-)-cocaine hydrochloride

: 426813-54-9
(1R,2S,3S,5S)-3-[[(4-methoxyphenyl)methyl]thio]-8-methyl-8-azabicyclo[3.2.1]octane-2-carbothioic acid S-[(4-methoxyphenyl)methyl] ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: aq. HCl / 20 h / Heating

2.1: EtMgBr / tetrahydrofuran / 20 °C

2.2: 4.5 percent / tetrahydrofuran / 14 h / 20 °C

With hydrogenchloride; ethylmagnesium bromide; In tetrahydrofuran;
DOI:10.1021/ja012376y