1-(5-chloro-2-nitro-benzenesulfonyl)-1H-pyrrole-2-carboxylic acid cyclopropylmethyl ester

Base Information

Chemical Name:1-(5-chloro-2-nitro-benzenesulfonyl)-1H-pyrrole-2-carboxylic acid cyclopropylmethyl ester
CAS No.:184090-31-1
Molecular Formula:C₁₅H₁₃ClN₂O₆S
Molecular Weight:384.797
Hs Code.:

1-(5-chloro-2-nitro-benzenesulfonyl)-1<i>H</i>-pyrrole-2-carboxylic acid cyclopropylmethyl ester

Synonyms:1-(5-chloro-2-nitro-benzenesulfonyl)-1H-pyrrole-2-carboxylic acid cyclopropylmethyl ester

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Chemical Property of 1-(5-chloro-2-nitro-benzenesulfonyl)-1H-pyrrole-2-carboxylic acid cyclopropylmethyl ester

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Technology Process of 1-(5-chloro-2-nitro-benzenesulfonyl)-1H-pyrrole-2-carboxylic acid cyclopropylmethyl ester

There total 2 articles about 1-(5-chloro-2-nitro-benzenesulfonyl)-1H-pyrrole-2-carboxylic acid cyclopropylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 21792-87-0
5-chloro-2-nitrobenzenesulfonyl chloride

: 685563-23-9
cyclopropylmethyl 1H-pyrrole-2-carboxylate

: 184090-31-1
1-(5-chloro-2-nitro-benzenesulfonyl)-1H-pyrrole-2-carboxylic acid cyclopropylmethyl ester

Guidance literature:: cyclopropylmethyl 1H-pyrrole-2-carboxylate; With 18-crown-6 ether; potassium tert-butylate; In tetrahydrofuran; for 0.25h;

5-chloro-2-nitrobenzenesulfonyl chloride; In tetrahydrofuran; at 20 ℃; for 3.5h;
DOI:10.1016/j.farmac.2003.11.004

Reference yield:

: 35302-72-8
pyrrol-2-yl trichloromethyl ketone

: 184090-31-1
1-(5-chloro-2-nitro-benzenesulfonyl)-1H-pyrrole-2-carboxylic acid cyclopropylmethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 96 percent / K₂CO₃ / 17 h / 60 °C

2.1: t-BuOK; 18-crown-6 / tetrahydrofuran / 0.25 h

2.2: 81 percent / tetrahydrofuran / 3.5 h / 20 °C

With 18-crown-6 ether; potassium tert-butylate; potassium carbonate; In tetrahydrofuran;
DOI:10.1016/j.farmac.2003.11.004