5,6-benzo-3,8,11,13-tetraoxo-2,2,9,9-tetramethyl-12,12-diethyl-1,4,7,10-tetraazacyclotridecane

Base Information

• Chemical Name: 5,6-benzo-3,8,11,13-tetraoxo-2,2,9,9-tetramethyl-12,12-diethyl-1,4,7,10-tetraazacyclotridecane
• CAS No.: 136668-04-7
• Molecular Formula: C₂₁H₃₀N₄O₄
• Molecular Weight: 402.494
• Mol file: 136668-04-7.mol

Synonyms:5,6-benzo-3,8,11,13-tetraoxo-2,2,9,9-tetramethyl-12,12-diethyl-1,4,7,10-tetraazacyclotridecane

Chemical Property of 5,6-benzo-3,8,11,13-tetraoxo-2,2,9,9-tetramethyl-12,12-diethyl-1,4,7,10-tetraazacyclotridecane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5,6-benzo-3,8,11,13-tetraoxo-2,2,9,9-tetramethyl-12,12-diethyl-1,4,7,10-tetraazacyclotridecane

There total 1 articles about 5,6-benzo-3,8,11,13-tetraoxo-2,2,9,9-tetramethyl-12,12-diethyl-1,4,7,10-tetraazacyclotridecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.3%

2-amino-N-[2-(2-amino-2-methyl-propionylamino)-phenyl]-2-methyl-propionamide (136668-01-4) + diethylmalonyl chloride (54505-72-5) → 5,6-benzo-3,8,11,13-tetraoxo-2,2,9,9-tetramethyl-12,12-diethyl-1,4,7,10-tetraazacyclotridecane (136668-04-7) + 2-(1-{2-[2-(2-Chlorocarbonyl-2-ethyl-butyrylamino)-2-methyl-propionylamino]-phenylcarbamoyl}-1-methyl-ethylcarbamoyl)-2-ethyl-butyryl chloride

Guidance literature:

With triethylamine; In dichloromethane; for 12h;

DOI:10.1021/ja00022a033

Reference yield:

5,6-benzo-3,8,11,13-tetraoxo-2,2,9,9-tetramethyl-12,12-diethyl-1,4,7,10-tetraazacyclotridecane (136668-04-7) → C21H26CoN4O4*C6H6*3H2O

Guidance literature:

Multi-step reaction with 2 steps

1: tert-butyllithium / tetrahydrofuran; pentane

2: dichloromethane; benzene

With tert-butyllithium; In tetrahydrofuran; dichloromethane; pentane; benzene;

DOI:10.1021/ja00022a033

upstream raw materials:

2-amino-N-[2-(2-amino-2-methyl-propionylamino)-phenyl]-2-methyl-propionamide

diethylmalonyl chloride