ethyl (5-amino-1,2-dihydro-2-oxo-3-phenylpyrido<3,4-b>pyrazin-7-yl)carbamate

Base Information

• Chemical Name: ethyl (5-amino-1,2-dihydro-2-oxo-3-phenylpyrido<3,4-b>pyrazin-7-yl)carbamate
• CAS No.: 130167-79-2
• Molecular Formula: 5C₁₆H₁₅N₅O₃*6ClH
• Molecular Weight: 1845.4
• Mol file: 130167-79-2.mol

Synonyms:ethyl (5-amino-1,2-dihydro-2-oxo-3-phenylpyrido<3,4-b>pyrazin-7-yl)carbamate

Chemical Property of ethyl (5-amino-1,2-dihydro-2-oxo-3-phenylpyrido<3,4-b>pyrazin-7-yl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl (5-amino-1,2-dihydro-2-oxo-3-phenylpyrido<3,4-b>pyrazin-7-yl)carbamate

There total 3 articles about ethyl (5-amino-1,2-dihydro-2-oxo-3-phenylpyrido<3,4-b>pyrazin-7-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

ethyl <5-<(diphenylmethyl)amino>-1,2-dihydro-2-oxo-3-phenylpyrido<3,4-b>pyrazin-7-yl>carbamate (130145-52-7) → ethyl (5-amino-1,2-dihydro-2-oxo-3-phenylpyrido<3,4-b>pyrazin-7-yl)carbamate (130167-79-2)

Guidance literature:

With hydrogenchloride; for 18h;

DOI:10.1021/jm00173a021

Reference yield:

phenylglyoxylic acid ethyl ester (1603-79-8) → ethyl (5-amino-1,2-dihydro-2-oxo-3-phenylpyrido<3,4-b>pyrazin-7-yl)carbamate (130167-79-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 62 percent / EtONa / ethanol / 1.) RT, 18 h, 2.) reflux, 12 h

2: 97 percent / conc. HCl / 18 h

With hydrogenchloride; sodium ethanolate; In ethanol;

DOI:10.1021/jm00173a021

Reference yield:

ethyl <4,5-diamino-6-<(diphenylmethyl)amino>pyridin-2-yl>carbamate dihydrochloride (38359-80-7) → ethyl (5-amino-1,2-dihydro-2-oxo-3-phenylpyrido<3,4-b>pyrazin-7-yl)carbamate (130167-79-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 62 percent / EtONa / ethanol / 1.) RT, 18 h, 2.) reflux, 12 h

2: 97 percent / conc. HCl / 18 h

With hydrogenchloride; sodium ethanolate; In ethanol;

DOI:10.1021/jm00173a021

upstream raw materials:

ethyl <5-<(diphenylmethyl)amino>-1,2-dihydro-2-oxo-3-phenylpyrido<3,4-b>pyrazin-7-yl>carbamate

phenylglyoxylic acid ethyl ester

ethyl <4,5-diamino-6-<(diphenylmethyl)amino>pyridin-2-yl>carbamate dihydrochloride