N-(2-Aminoethyl)-1--1H-imidazole-4-acetamide

Base Information

• Chemical Name: N-(2-Aminoethyl)-1--1H-imidazole-4-acetamide
• CAS No.: 128870-19-9
• Molecular Formula: C₂₈H₃₀N₄O₃
• Molecular Weight: 470.571
• Mol file: 128870-19-9.mol

Synonyms:N-(2-Aminoethyl)-1--1H-imidazole-4-acetamide

Chemical Property of N-(2-Aminoethyl)-1--1H-imidazole-4-acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-Aminoethyl)-1--1H-imidazole-4-acetamide

There total 3 articles about N-(2-Aminoethyl)-1--1H-imidazole-4-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

1--1H-imidazole-4-acetic cid ethyl ester (128870-18-8) + ethylenediamine (107-15-3,85404-18-8) → N-(2-Aminoethyl)-1--1H-imidazole-4-acetamide (128870-19-9)

Guidance literature:

for 48h; Ambient temperature;

DOI:10.1021/jo00304a026

Reference yield:

imidazole-4-acetic acid hydrochloride (3251-69-2) → N-(2-Aminoethyl)-1--1H-imidazole-4-acetamide (128870-19-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 92 percent / conc. H₂SO₄ / 12 h / Heating

2: 76 percent / Et₃N / CH₂Cl₂

3: 91 percent / 48 h / Ambient temperature

With sulfuric acid; triethylamine; In dichloromethane;

DOI:10.1021/jo00304a026

Reference yield:

(1H-imidazol-4-yl)-acetic acid ethyl ester (28782-45-8) → N-(2-Aminoethyl)-1--1H-imidazole-4-acetamide (128870-19-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 76 percent / Et₃N / CH₂Cl₂

2: 91 percent / 48 h / Ambient temperature

With triethylamine; In dichloromethane;

DOI:10.1021/jo00304a026

upstream raw materials:

1--1H-imidazole-4-acetic cid ethyl ester

ethylenediamine

imidazole-4-acetic acid hydrochloride

(1H-imidazol-4-yl)-acetic acid ethyl ester

Downstream raw materials:

5'-O--5-<3-<<2-<<<1--1H-imidazol-4-yl>acetyl>amino>ethyl>amino>-3-oxopropyl>-2'-deoxyuridine