(2S)-2-[(2S,3S,4S)-1-benzyl-3,4-di-tert-butoxypyrrolidin-2-yl]-2-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]ethanol

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Chemical Name:(2S)-2-[(2S,3S,4S)-1-benzyl-3,4-di-tert-butoxypyrrolidin-2-yl]-2-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]ethanol
CAS No.:1294516-51-0
Molecular Formula:C₂₆H₄₃NO₅
Molecular Weight:449.631
Hs Code.:

Synonyms:(2S)-2-[(2S,3S,4S)-1-benzyl-3,4-di-tert-butoxypyrrolidin-2-yl]-2-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]ethanol

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Chemical Property of (2S)-2-[(2S,3S,4S)-1-benzyl-3,4-di-tert-butoxypyrrolidin-2-yl]-2-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]ethanol

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Technology Process of (2S)-2-[(2S,3S,4S)-1-benzyl-3,4-di-tert-butoxypyrrolidin-2-yl]-2-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]ethanol

There total 5 articles about (2S)-2-[(2S,3S,4S)-1-benzyl-3,4-di-tert-butoxypyrrolidin-2-yl]-2-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1294516-50-9
(2S,3S)-3-[(2S,3S,4S)-1-benzyl-3,4-di-tert-butoxypyrrolidin-2-yl]butane-1,2,4-triol

: 77-76-9
2,2-dimethoxy-propane

: 1294516-51-0
(2S)-2-[(2S,3S,4S)-1-benzyl-3,4-di-tert-butoxypyrrolidin-2-yl]-2-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]ethanol

Guidance literature:: With toluene-4-sulfonic acid; In water; for 2h; Inert atmosphere;
DOI:10.1055/s-0030-1259293

Reference yield:

: 879558-97-1
7,8-di-tert-butoxy-hexahydro-furo[3,4-d]pyrrolo[1,2-b]isoxazol-1-one

: 1294516-51-0
(2S)-2-[(2S,3S,4S)-1-benzyl-3,4-di-tert-butoxypyrrolidin-2-yl]-2-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]ethanol

Guidance literature:: Multi-step reaction with 4 steps

1: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 0 - 20 °C

2: 20 % Pd(OH)2/C; hydrogen / methanol / 26 h

3: potassium carbonate / acetonitrile / 20 °C

4: toluene-4-sulfonic acid / water / 2 h / Inert atmosphere

With lithium aluminium tetrahydride; 20 % Pd(OH)2/C; hydrogen; potassium carbonate; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; diethyl ether; water; acetonitrile;
DOI:10.1055/s-0030-1259293

Reference yield:

: 1294516-49-6
(2S,3S)-3-[(2S,3S,4S)-3,4-di-tert-butoxypyrrolidin-2-yl]butane-1,2,4-triol

: 1294516-51-0
(2S)-2-[(2S,3S,4S)-1-benzyl-3,4-di-tert-butoxypyrrolidin-2-yl]-2-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]ethanol

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / acetonitrile / 20 °C

2: toluene-4-sulfonic acid / water / 2 h / Inert atmosphere

With potassium carbonate; toluene-4-sulfonic acid; In water; acetonitrile;
DOI:10.1055/s-0030-1259293