1-(4-chlorophenyl)-4-((dimethylamino)methylene)-3-methyl-1H-pyrazol-5(4H)-one

Base Information

• Chemical Name: 1-(4-chlorophenyl)-4-((dimethylamino)methylene)-3-methyl-1H-pyrazol-5(4H)-one
• CAS No.: 118030-33-4
• Molecular Formula: C₁₃H₁₄ClN₃O
• Molecular Weight: 263.727

Synonyms:1-(4-chlorophenyl)-4-((dimethylamino)methylene)-3-methyl-1H-pyrazol-5(4H)-one

Chemical Property of 1-(4-chlorophenyl)-4-((dimethylamino)methylene)-3-methyl-1H-pyrazol-5(4H)-one

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Technology Process of 1-(4-chlorophenyl)-4-((dimethylamino)methylene)-3-methyl-1H-pyrazol-5(4H)-one

There total 2 articles about 1-(4-chlorophenyl)-4-((dimethylamino)methylene)-3-methyl-1H-pyrazol-5(4H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

1-(4-chlorophenyl)-3-methyl-2-pyrazolin-5-one (13024-90-3) + N,N-dimethylformamide diethyl diacetal (1188-33-6) → 1-(4-chlorophenyl)-4-((dimethylamino)methylene)-3-methyl-1H-pyrazol-5(4H)-one (118030-33-4)

Guidance literature:

In isopropyl alcohol; at 20 ℃; for 22h;

DOI:10.1248/cpb.c13-00314

Reference yield:

N,N-dimethyl-formamide (68-12-2,33513-42-7) + 1-(4-chlorophenyl)-3-methyl-2-pyrazolin-5-one (13024-90-3) → 1-(4-chlorophenyl)-4-((dimethylamino)methylene)-3-methyl-1H-pyrazol-5(4H)-one (118030-33-4)

Guidance literature:

N,N-dimethyl-formamide; 1-(4-chlorophenyl)-3-methyl-2-pyrazolin-5-one; With trichlorophosphate; at 80 ℃; for 2h;

With sodium hydroxide; In water;

DOI:10.1016/j.bmc.2009.05.058

Reference yield: 83.0%

diazoacetic acid ethyl ester (623-73-4) + 1-(4-chlorophenyl)-4-((dimethylamino)methylene)-3-methyl-1H-pyrazol-5(4H)-one (118030-33-4) → ethyl 1-(4-chlorophenyl)-3-methyl-3a,6a-dihydro-1H-furo[2,3-c]pyrazole-5-carboxylate

Guidance literature:

With indium(III) triflate; In 1,2-dichloro-ethane; for 6h; Reflux;

DOI:10.1021/acs.orglett.2c00019

upstream raw materials:

N,N-dimethyl-formamide

1-(4-chlorophenyl)-3-methyl-2-pyrazolin-5-one

N,N-dimethylformamide diethyl diacetal

Downstream raw materials:

1-(4-chlorophenyl)-4-(hydroxymethylene)-3-methyl-1H-pyrazol-5(4H)-one

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