{(R)-1-[(2R,5S)-5-((R)-2-Benzyloxy-1-methyl-ethyl)-tetrahydro-furan-2-ylmethyl]-propoxy}-tert-butyl-dimethyl-silane

Base Information

Chemical Name:{(R)-1-[(2R,5S)-5-((R)-2-Benzyloxy-1-methyl-ethyl)-tetrahydro-furan-2-ylmethyl]-propoxy}-tert-butyl-dimethyl-silane
CAS No.:197517-60-5
Molecular Formula:C₂₄H₄₂O₃Si
Molecular Weight:406.681
Hs Code.:

Synonyms:{(R)-1-[(2R,5S)-5-((R)-2-Benzyloxy-1-methyl-ethyl)-tetrahydro-furan-2-ylmethyl]-propoxy}-tert-butyl-dimethyl-silane

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Chemical Property of {(R)-1-[(2R,5S)-5-((R)-2-Benzyloxy-1-methyl-ethyl)-tetrahydro-furan-2-ylmethyl]-propoxy}-tert-butyl-dimethyl-silane

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Technology Process of {(R)-1-[(2R,5S)-5-((R)-2-Benzyloxy-1-methyl-ethyl)-tetrahydro-furan-2-ylmethyl]-propoxy}-tert-butyl-dimethyl-silane

There total 18 articles about {(R)-1-[(2R,5S)-5-((R)-2-Benzyloxy-1-methyl-ethyl)-tetrahydro-furan-2-ylmethyl]-propoxy}-tert-butyl-dimethyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 197517-58-1
(R)-1-[(2R,5S)-5-((R)-2-Benzyloxy-1-methyl-ethyl)-tetrahydro-furan-2-yl]-butan-2-ol

: 197517-60-5
{(R)-1-[(2R,5S)-5-((R)-2-Benzyloxy-1-methyl-ethyl)-tetrahydro-furan-2-ylmethyl]-propoxy}-tert-butyl-dimethyl-silane

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide;
DOI:10.1055/s-1997-1547

Reference yield: 83.0%

: 197517-85-4
((R)-1-{(R)-[(2R,5S)-5-((R)-2-Benzyloxy-1-methyl-ethyl)-tetrahydro-furan-2-yl]-iodo-methyl}-propoxy)-tert-butyl-dimethyl-silane

: 197517-60-5
{(R)-1-[(2R,5S)-5-((R)-2-Benzyloxy-1-methyl-ethyl)-tetrahydro-furan-2-ylmethyl]-propoxy}-tert-butyl-dimethyl-silane

Guidance literature:: With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In toluene; Heating;
DOI:10.1055/s-1997-1547

Reference yield:

: 197517-45-6
(2R,3R)-4-benzyloxy-1,2-epoxy-3-methylbutane

: 197517-60-5
{(R)-1-[(2R,5S)-5-((R)-2-Benzyloxy-1-methyl-ethyl)-tetrahydro-furan-2-ylmethyl]-propoxy}-tert-butyl-dimethyl-silane

Guidance literature:: Multi-step reaction with 8 steps

1: 99 percent / CuI / diethyl ether

2: Amberlyst H-15 / hexane

3: 86 percent / OsO₄, NaIO₄ / dioxane; H₂O

4: 82 percent / NaH / tetrahydrofuran / -20 - 0 °C

5: 92 percent / I₂, NaHCO₃ / acetonitrile / 5 °C

6: NaBH₄, MgBr₂*OEt₂ / ethanol / -78 °C

7: n-Bu₃SnH, AIBN / toluene / Heating

8: 99 percent / imidazole / dimethylformamide

With 1H-imidazole; sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; 2,2'-azobis(isobutyronitrile); Amberlyst H-15; iodine; tri-n-butyl-tin hydride; sodium hydride; sodium hydrogencarbonate; magnesium bromide; copper(l) iodide; In tetrahydrofuran; 1,4-dioxane; diethyl ether; ethanol; hexane; water; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1055/s-1997-1547