3,3-Dimethyl-1β-<<(tert-butyldimethylsilyl)oxy>methyl>-2α-<(phenylsulfonyl)methyl>cyclobutane

Base Information

Chemical Name:3,3-Dimethyl-1β-<<(tert-butyldimethylsilyl)oxy>methyl>-2α-<(phenylsulfonyl)methyl>cyclobutane
CAS No.:81491-30-7
Molecular Formula:C₂₀H₃₄O₃SSi
Molecular Weight:382.64
Hs Code.:

Synonyms:3,3-Dimethyl-1β-<<(tert-butyldimethylsilyl)oxy>methyl>-2α-<(phenylsulfonyl)methyl>cyclobutane

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Chemical Property of 3,3-Dimethyl-1β-<<(tert-butyldimethylsilyl)oxy>methyl>-2α-<(phenylsulfonyl)methyl>cyclobutane

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Technology Process of 3,3-Dimethyl-1β-<<(tert-butyldimethylsilyl)oxy>methyl>-2α-<(phenylsulfonyl)methyl>cyclobutane

There total 10 articles about 3,3-Dimethyl-1β-<<(tert-butyldimethylsilyl)oxy>methyl>-2α-<(phenylsulfonyl)methyl>cyclobutane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7605-30-3
ethyl 2-phenylsulfonylacetate

: 81491-30-7
3,3-Dimethyl-1β-<<(tert-butyldimethylsilyl)oxy>methyl>-2α-<(phenylsulfonyl)methyl>cyclobutane

Guidance literature:: Multi-step reaction with 6 steps

1: 357 mg / potassium tert-butoxide / tetrahydrofuran; dimethylsulfoxide / 144 h / Ambient temperature

2: 2percent KOH / H₂O; ethanol / 1.)1 h, r.t., 2.)2 h, reflux

3: pyridine / 2 h / Heating

4: K₂CO₃ / acetone / 12 h / Heating

5: 1.33 g / LiAlH₄ / diethyl ether / 0.33 h / 0 °C

6: 1.65 g / Imidazol / dimethylformamide / Ambient temperature

With 1H-imidazole; potassium hydroxide; lithium aluminium tetrahydride; potassium tert-butylate; potassium carbonate; In tetrahydrofuran; pyridine; diethyl ether; ethanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jo00187a006

Reference yield:

: 81491-55-6
(1R,2S)-2-Hydroxymethyl-3,3-dimethyl-cyclobutanecarboxylic acid methyl ester

: 81491-30-7
3,3-Dimethyl-1β-<<(tert-butyldimethylsilyl)oxy>methyl>-2α-<(phenylsulfonyl)methyl>cyclobutane

Guidance literature:: Multi-step reaction with 4 steps

1: tri-n-butylphosphine / pyridine

3: 1.33 g / LiAlH₄ / diethyl ether / 0.33 h / 0 °C

4: 1.65 g / Imidazol / dimethylformamide / Ambient temperature

With 1H-imidazole; lithium aluminium tetrahydride; tributylphosphine; In pyridine; diethyl ether; N,N-dimethyl-formamide;
DOI:10.1021/jo00187a006

Reference yield:

: 81491-28-3
(1S,2R)-3,3-Dimethyl-2-phenylsulfanylmethyl-cyclobutanecarboxylic acid methyl ester

: 81491-30-7
3,3-Dimethyl-1β-<<(tert-butyldimethylsilyl)oxy>methyl>-2α-<(phenylsulfonyl)methyl>cyclobutane

Guidance literature:: Multi-step reaction with 3 steps

2: 1.33 g / LiAlH₄ / diethyl ether / 0.33 h / 0 °C

3: 1.65 g / Imidazol / dimethylformamide / Ambient temperature

With 1H-imidazole; lithium aluminium tetrahydride; In diethyl ether; N,N-dimethyl-formamide;
DOI:10.1021/jo00187a006