(5-(4-(diethylamino)butyl)-4-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)-4H-1,2,4-triazol-3-yl)methanol

Base Information

Chemical Name:(5-(4-(diethylamino)butyl)-4-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)-4H-1,2,4-triazol-3-yl)methanol
CAS No.:1432488-11-3
Molecular Formula:C₂₅H₃₁F₃N₄O
Molecular Weight:460.543
Hs Code.:

Synonyms:(5-(4-(diethylamino)butyl)-4-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)-4H-1,2,4-triazol-3-yl)methanol

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Chemical Property of (5-(4-(diethylamino)butyl)-4-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)-4H-1,2,4-triazol-3-yl)methanol

Chemical Property:

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Technology Process of (5-(4-(diethylamino)butyl)-4-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)-4H-1,2,4-triazol-3-yl)methanol

There total 7 articles about (5-(4-(diethylamino)butyl)-4-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)-4H-1,2,4-triazol-3-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 1432488-10-2
N,N-diethyl-4-(4-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)-4H-1,2,4-triazol-3-yl)butan-1-amine

: 1432488-11-3
(5-(4-(diethylamino)butyl)-4-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)-4H-1,2,4-triazol-3-yl)methanol

Guidance literature:: In water; for 4h; Reflux;
DOI:10.1016/j.bmcl.2013.03.062

Reference yield:

: 2034-25-5
5-hydroxypentanoic acid hydrazide

: 1432488-11-3
(5-(4-(diethylamino)butyl)-4-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)-4H-1,2,4-triazol-3-yl)methanol

Guidance literature:: Multi-step reaction with 6 steps

1: ethanol / 2 h / Reflux

2: dihydrogen peroxide; acetic acid / dichloromethane / 0.08 h / 35 °C

3: caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 9 h / Reflux; Inert atmosphere

4: oxalyl dichloride; dimethyl sulfoxide; triethylamine / dichloromethane / -65 °C

5: sodium tris(acetoxy)borohydride / dichloromethane / 2 h / 20 °C

6: water / 4 h / Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; oxalyl dichloride; dihydrogen peroxide; sodium tris(acetoxy)borohydride; caesium carbonate; acetic acid; dimethyl sulfoxide; triethylamine; In ethanol; dichloromethane; water;
DOI:10.1016/j.bmcl.2013.03.062

Reference yield:

: 1432488-07-7
4-(4-(4-bromobenzyl)-4H-1,2,4-triazol-3-yl)butan-1-ol

: 1432488-11-3
(5-(4-(diethylamino)butyl)-4-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)-4H-1,2,4-triazol-3-yl)methanol

Guidance literature:: Multi-step reaction with 4 steps

1: caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 9 h / Reflux; Inert atmosphere

2: oxalyl dichloride; dimethyl sulfoxide; triethylamine / dichloromethane / -65 °C

3: sodium tris(acetoxy)borohydride / dichloromethane / 2 h / 20 °C

4: water / 4 h / Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; oxalyl dichloride; sodium tris(acetoxy)borohydride; caesium carbonate; dimethyl sulfoxide; triethylamine; In dichloromethane; water;
DOI:10.1016/j.bmcl.2013.03.062