4-(6-benzyloxycarbonyl-hexanoylamino)-4-[2-(2,5-dioxo-pyrrolidin-1-yloxycarbonyl)-ethyl]-heptanedioic acid bis-(2,5-dioxo-pyrrolidin-1-yl) ester

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Chemical Name:4-(6-benzyloxycarbonyl-hexanoylamino)-4-[2-(2,5-dioxo-pyrrolidin-1-yloxycarbonyl)-ethyl]-heptanedioic acid bis-(2,5-dioxo-pyrrolidin-1-yl) ester
CAS No.:880359-85-3
Molecular Formula:C₃₆H₄₂N₄O₁₅
Molecular Weight:770.747
Hs Code.:

4-(6-benzyloxycarbonyl-hexanoylamino)-4-[2-(2,5-dioxo-pyrrolidin-1-yloxycarbonyl)-ethyl]-heptanedioic acid bis-(2,5-dioxo-pyrrolidin-1-yl) ester

Synonyms:4-(6-benzyloxycarbonyl-hexanoylamino)-4-[2-(2,5-dioxo-pyrrolidin-1-yloxycarbonyl)-ethyl]-heptanedioic acid bis-(2,5-dioxo-pyrrolidin-1-yl) ester

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Chemical Property of 4-(6-benzyloxycarbonyl-hexanoylamino)-4-[2-(2,5-dioxo-pyrrolidin-1-yloxycarbonyl)-ethyl]-heptanedioic acid bis-(2,5-dioxo-pyrrolidin-1-yl) ester

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Technology Process of 4-(6-benzyloxycarbonyl-hexanoylamino)-4-[2-(2,5-dioxo-pyrrolidin-1-yloxycarbonyl)-ethyl]-heptanedioic acid bis-(2,5-dioxo-pyrrolidin-1-yl) ester

There total 4 articles about 4-(6-benzyloxycarbonyl-hexanoylamino)-4-[2-(2,5-dioxo-pyrrolidin-1-yloxycarbonyl)-ethyl]-heptanedioic acid bis-(2,5-dioxo-pyrrolidin-1-yl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 880359-83-1
4-(6-benzyloxycarbonyl-hexanoylamino)-4-(2-tert-butoxycarbonyl-ethyl)-heptanedioic acid di-tert-butyl ester

: 880359-85-3
4-(6-benzyloxycarbonyl-hexanoylamino)-4-[2-(2,5-dioxo-pyrrolidin-1-yloxycarbonyl)-ethyl]-heptanedioic acid bis-(2,5-dioxo-pyrrolidin-1-yl) ester

Guidance literature:: Multi-step reaction with 2 steps

1: TFA / CH₂Cl₂ / 2 h

2: EDAC / dimethylformamide / 14 h

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2005.11.062

Reference yield:

: 15513-04-9
pimelic acid monobenzyl ester

: 880359-85-3
4-(6-benzyloxycarbonyl-hexanoylamino)-4-[2-(2,5-dioxo-pyrrolidin-1-yloxycarbonyl)-ethyl]-heptanedioic acid bis-(2,5-dioxo-pyrrolidin-1-yl) ester

Guidance literature:: Multi-step reaction with 4 steps

1: oxalyl chloride; DMF / CH₂Cl₂

2: Et₃N / CH₂Cl₂ / 1 h

3: TFA / CH₂Cl₂ / 2 h

4: EDAC / dimethylformamide / 14 h

With oxalyl dichloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N,N-dimethyl-formamide; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2005.11.062

Reference yield:

: 78582-38-4
pimelic acid chloride monobenzyl ester

: 880359-85-3
4-(6-benzyloxycarbonyl-hexanoylamino)-4-[2-(2,5-dioxo-pyrrolidin-1-yloxycarbonyl)-ethyl]-heptanedioic acid bis-(2,5-dioxo-pyrrolidin-1-yl) ester

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N / CH₂Cl₂ / 1 h

2: TFA / CH₂Cl₂ / 2 h

3: EDAC / dimethylformamide / 14 h

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2005.11.062