3-(4-aminophenyl)-5-({[(3-hydroxypropyl)amino]carbonyl}amino)isothiazol-4 carboxamide

Base Information

Chemical Name:3-(4-aminophenyl)-5-({[(3-hydroxypropyl)amino]carbonyl}amino)isothiazol-4 carboxamide
CAS No.:1446246-96-3
Molecular Formula:C₁₄H₁₇N₅O₃S
Molecular Weight:335.387
Hs Code.:

Synonyms:3-(4-aminophenyl)-5-({[(3-hydroxypropyl)amino]carbonyl}amino)isothiazol-4 carboxamide

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Chemical Property of 3-(4-aminophenyl)-5-({[(3-hydroxypropyl)amino]carbonyl}amino)isothiazol-4 carboxamide

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Technology Process of 3-(4-aminophenyl)-5-({[(3-hydroxypropyl)amino]carbonyl}amino)isothiazol-4 carboxamide

There total 11 articles about 3-(4-aminophenyl)-5-({[(3-hydroxypropyl)amino]carbonyl}amino)isothiazol-4 carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1446246-94-1
3-[({[4-(aminocarbonyl)-3-(4-aminophenyl)isothiazol-5-yl]amino}carbonyl)amino]propyl acetate

: 1446246-96-3
3-(4-aminophenyl)-5-({[(3-hydroxypropyl)amino]carbonyl}amino)isothiazol-4 carboxamide

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; N,N-dimethyl-formamide; for 24h; under 4137.29 Torr; Autoclave;

Reference yield:

: 909028-96-2
3-amino-3-(4-nitrophenyl)-2-thioformamidoacrylonitrile

: 1446246-96-3
3-(4-aminophenyl)-5-({[(3-hydroxypropyl)amino]carbonyl}amino)isothiazol-4 carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: dihydrogen peroxide / ethanol / 22 h / Inert atmosphere

2.1: potassium carbonate / tetrahydrofuran; dimethyl sulfoxide / 0.25 h / 20 °C

2.2: 20 °C

3.1: sulfuric acid / 1.83 h / 45 °C

3.2: Cooling with ice

4.1: sodium tetrahydroborate / tetrahydrofuran / Reflux

4.2: 2 h / Reflux

5.1: pyridine / 2.16 h / 20 °C

6.1: hydrogen; palladium 10% on activated carbon / tetrahydrofuran; N,N-dimethyl-formamide / 24 h / 4137.29 Torr / Autoclave

7.1: hydrogen; palladium 10% on activated carbon / tetrahydrofuran; N,N-dimethyl-formamide / 24 h / 4137.29 Torr / Autoclave

With pyridine; sodium tetrahydroborate; sulfuric acid; palladium 10% on activated carbon; hydrogen; dihydrogen peroxide; potassium carbonate; In tetrahydrofuran; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 605661-26-5
2-[amino(4-nitrophenyl)methylene]malononitrile

: 1446246-96-3
3-(4-aminophenyl)-5-({[(3-hydroxypropyl)amino]carbonyl}amino)isothiazol-4 carboxamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: O,O-Diethyl hydrogen phosphorodithioate / ethanol; water / 100 °C / Inert atmosphere

2.1: dihydrogen peroxide / ethanol / 22 h / Inert atmosphere

3.1: potassium carbonate / tetrahydrofuran; dimethyl sulfoxide / 0.25 h / 20 °C

3.2: 20 °C

4.1: sulfuric acid / 1.83 h / 45 °C

4.2: Cooling with ice

5.1: sodium tetrahydroborate / tetrahydrofuran / Reflux

5.2: 2 h / Reflux

6.1: pyridine / 2.16 h / 20 °C

7.1: hydrogen; palladium 10% on activated carbon / tetrahydrofuran; N,N-dimethyl-formamide / 24 h / 4137.29 Torr / Autoclave

8.1: hydrogen; palladium 10% on activated carbon / tetrahydrofuran; N,N-dimethyl-formamide / 24 h / 4137.29 Torr / Autoclave

With pyridine; sodium tetrahydroborate; sulfuric acid; palladium 10% on activated carbon; hydrogen; dihydrogen peroxide; potassium carbonate; O,O-Diethyl hydrogen phosphorodithioate; In tetrahydrofuran; ethanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide;