2,5-diamino-6-chloro-4-<(cyclohex-3-en-1-yl)amino>pyrimidine

Base Information

• Chemical Name: 2,5-diamino-6-chloro-4-<(cyclohex-3-en-1-yl)amino>pyrimidine
• CAS No.: 131853-60-6
• Molecular Formula: C₁₀H₁₄ClN₅
• Molecular Weight: 239.708
• Mol file: 131853-60-6.mol

Synonyms:2,5-diamino-6-chloro-4-<(cyclohex-3-en-1-yl)amino>pyrimidine

Chemical Property of 2,5-diamino-6-chloro-4-<(cyclohex-3-en-1-yl)amino>pyrimidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,5-diamino-6-chloro-4-<(cyclohex-3-en-1-yl)amino>pyrimidine

There total 1 articles about 2,5-diamino-6-chloro-4-<(cyclohex-3-en-1-yl)amino>pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

2,5-diamino-4,6-dichloropyrimidine (55583-59-0) + 3-Cyclohexenyl-1-amine (2655-68-7) → 2,5-diamino-6-chloro-4-<(cyclohex-3-en-1-yl)amino>pyrimidine (131853-60-6)

Guidance literature:

With triethylamine; In butan-1-ol; at 100 ℃; for 48h;

DOI:10.1002/jhet.5570270652

Reference yield: 75.0%

2,5-diamino-6-chloro-4-<(cyclohex-3-en-1-yl)amino>pyrimidine (131853-60-6) + orthoformic acid triethyl ester (122-51-0) → 2-amino-6-chloro-9H-9-(cyclohex-3-en-1-yl)purine (131853-61-7)

Guidance literature:

hydrogenchloride; In N,N-dimethyl acetamide; Ambient temperature;

DOI:10.1002/jhet.5570270652

Reference yield:

2,5-diamino-6-chloro-4-<(cyclohex-3-en-1-yl)amino>pyrimidine (131853-60-6) → 9-(dihydroxy-1,6-hex-3-yl)guanine (144175-45-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 75 percent / 12N HCl / N,N-dimethyl-acetamide / Ambient temperature

2: 80 percent / 1M HCl / 6 h / Heating

3: N-methylmorpholine N-oxide, OsO₄ / H₂O; methanol; 2-methyl-propan-2-ol / 0.75 h / 90 °C

4: 1.) sodium periodate 2.) sodium borohydride / 1.) H₂O, 3 h, r.t. 2.) H₂O, 2 h, 0 deg C

With hydrogenchloride; sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; 4-methylmorpholine N-oxide; hydrogenchloride; In methanol; N,N-dimethyl acetamide; water; tert-butyl alcohol;

DOI:10.1002/jhet.5570270652

upstream raw materials:

2,5-diamino-4,6-dichloropyrimidine

3-Cyclohexenyl-1-amine

Downstream raw materials:

2-amino-6-chloro-9H-9-(cyclohex-3-en-1-yl)purine

9-(dihydroxy-1,6-hex-3-yl)guanine