(E)-1-fluoro-3-(3-methylbuta-1,3-dien-1-yl)benzene

Base Information

• Chemical Name: (E)-1-fluoro-3-(3-methylbuta-1,3-dien-1-yl)benzene
• CAS No.: 1446318-96-2
• Molecular Formula: C₁₁H₁₁F
• Molecular Weight: 162.207
• Mol file: 1446318-96-2.mol

Synonyms:(E)-1-fluoro-3-(3-methylbuta-1,3-dien-1-yl)benzene

Chemical Property of (E)-1-fluoro-3-(3-methylbuta-1,3-dien-1-yl)benzene

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of (E)-1-fluoro-3-(3-methylbuta-1,3-dien-1-yl)benzene

There total 2 articles about (E)-1-fluoro-3-(3-methylbuta-1,3-dien-1-yl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

4-(3-fluorophenyl)-2-methylbut-3-yn-2-ol (893746-64-0) → (E)-1-fluoro-3-(3-methylbuta-1,3-dien-1-yl)benzene (1446318-96-2)

Guidance literature:

With aluminum (III) chloride; lithium aluminium tetrahydride; In tetrahydrofuran; at 70 ℃; for 5h; stereoselective reaction;

DOI:10.1080/00397911.2012.711881

Reference yield:

Methyltriphenylphosphonium bromide (1779-49-3) + (E)-4-(3-fluorophenyl)but-3-en-2-one (38675-91-1) → (E)-1-fluoro-3-(3-methylbuta-1,3-dien-1-yl)benzene (1446318-96-2)

Guidance literature:

Methyltriphenylphosphonium bromide; With sodium hydride; In tetrahydrofuran; at 60 ℃; for 1h;

(E)-4-(3-fluorophenyl)but-3-en-2-one; In tetrahydrofuran; at 60 ℃;

DOI:10.1021/acs.joc.8b01771

Reference yield: 90.0%

methyl 4-phenyl-2-oxo-3-butenoate (107969-78-8,6395-86-4) + (E)-1-fluoro-3-(3-methylbuta-1,3-dien-1-yl)benzene (1446318-96-2) → methyl 2-((1′R,2′S,3′R)-3-fluoro-5′-methyl-1′,2′,3′,4′-tetrahydro[1,1′:3′,1′′-terphenyl]-2′-yl)-2-oxoacetate

Guidance literature:

methyl 4-phenyl-2-oxo-3-butenoate; With C₄₅H₇₂N₄O₄; zinc trifluoromethanesulfonate; In 1,2-dichloro-ethane; at 35 ℃; for 0.5h; Inert atmosphere;

(E)-1-fluoro-3-(3-methylbuta-1,3-dien-1-yl)benzene; In 1,2-dichloro-ethane; at 35 ℃; for 24h; stereoselective reaction; Inert atmosphere;

DOI:10.1021/acs.joc.8b01771

upstream raw materials:

4-(3-fluorophenyl)-2-methylbut-3-yn-2-ol

Methyltriphenylphosphonium bromide

(E)-4-(3-fluorophenyl)but-3-en-2-one