2,3-Dihydro-5-(4(E))-3-hydroxy-[4-methyl-6-(2,6,6-trimethylcyclohexenyl)-4-hexen-1-ynyl]-5-methyl-1,4-dioxepin

Base Information

• Chemical Name: 2,3-Dihydro-5-(4(E))-3-hydroxy-[4-methyl-6-(2,6,6-trimethylcyclohexenyl)-4-hexen-1-ynyl]-5-methyl-1,4-dioxepin
• CAS No.: 1027025-10-0
• Molecular Formula: C₂₂H₃₂O₃
• Molecular Weight: 344.494
• Mol file: 1027025-10-0.mol

Synonyms:2,3-Dihydro-5-(4(E))-3-hydroxy-[4-methyl-6-(2,6,6-trimethylcyclohexenyl)-4-hexen-1-ynyl]-5-methyl-1,4-dioxepin

Chemical Property of 2,3-Dihydro-5-(4(E))-3-hydroxy-[4-methyl-6-(2,6,6-trimethylcyclohexenyl)-4-hexen-1-ynyl]-5-methyl-1,4-dioxepin

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,3-Dihydro-5-(4(E))-3-hydroxy-[4-methyl-6-(2,6,6-trimethylcyclohexenyl)-4-hexen-1-ynyl]-5-methyl-1,4-dioxepin

There total 3 articles about 2,3-Dihydro-5-(4(E))-3-hydroxy-[4-methyl-6-(2,6,6-trimethylcyclohexenyl)-4-hexen-1-ynyl]-5-methyl-1,4-dioxepin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

(E)-2-methyl-4-(2,6,6-trimethyl-1-cyclohexenyl)-2-butenal (14398-40-4) + 2,3-Dihydro-5-ethynyl-5-methyl-1,4-dioxepin (214967-70-1) → 2,3-Dihydro-5-(4(E))-3-hydroxy-[4-methyl-6-(2,6,6-trimethylcyclohexenyl)-4-hexen-1-ynyl]-5-methyl-1,4-dioxepin (1027025-10-0)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; hexane; at 25 ℃; for 1h;

DOI:10.1002/(SICI)1521-3765(19980904)4:9<1738::AID-CHEM1738>3.0.CO;2-P

Reference yield:

3-methyl-1,4-pentadiyne-3-ol (76783-21-6) → 2,3-Dihydro-5-(4(E))-3-hydroxy-[4-methyl-6-(2,6,6-trimethylcyclohexenyl)-4-hexen-1-ynyl]-5-methyl-1,4-dioxepin (1027025-10-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 60 percent / NaH / dimethylformamide / 1 h / 0 °C

2: KOH, H₂O / 3 h / Heating

3: 91 percent / BuLi / tetrahydrofuran; hexane / 1 h / 25 °C

With potassium hydroxide; n-butyllithium; water; sodium hydride; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;

DOI:10.1002/(SICI)1521-3765(19980904)4:9<1738::AID-CHEM1738>3.0.CO;2-P

Reference yield:

2-(1-Ethynyl-1-methyl-prop-2-ynyloxy)-ethanol (214967-59-6) → 2,3-Dihydro-5-(4(E))-3-hydroxy-[4-methyl-6-(2,6,6-trimethylcyclohexenyl)-4-hexen-1-ynyl]-5-methyl-1,4-dioxepin (1027025-10-0)

Guidance literature:

Multi-step reaction with 2 steps

1: KOH, H₂O / 3 h / Heating

2: 91 percent / BuLi / tetrahydrofuran; hexane / 1 h / 25 °C

With potassium hydroxide; n-butyllithium; water; In tetrahydrofuran; hexane;

DOI:10.1002/(SICI)1521-3765(19980904)4:9<1738::AID-CHEM1738>3.0.CO;2-P

upstream raw materials:

(E)-2-methyl-4-(2,6,6-trimethyl-1-cyclohexenyl)-2-butenal

2,3-Dihydro-5-ethynyl-5-methyl-1,4-dioxepin

3-methyl-1,4-pentadiyne-3-ol

2-(1-Ethynyl-1-methyl-prop-2-ynyloxy)-ethanol