6-acetamido-3-[2-[4-isopropyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl]ethyl]-5-methyl-1,2-benzisoxazole

Base Information

Chemical Name:6-acetamido-3-[2-[4-isopropyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl]ethyl]-5-methyl-1,2-benzisoxazole
CAS No.:515138-35-9
Molecular Formula:C₂₅H₂₄F₃N₃O₂S
Molecular Weight:487.546
Hs Code.:

Synonyms:6-acetamido-3-[2-[4-isopropyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl]ethyl]-5-methyl-1,2-benzisoxazole

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Chemical Property of 6-acetamido-3-[2-[4-isopropyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl]ethyl]-5-methyl-1,2-benzisoxazole

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Technology Process of 6-acetamido-3-[2-[4-isopropyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl]ethyl]-5-methyl-1,2-benzisoxazole

There total 5 articles about 6-acetamido-3-[2-[4-isopropyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl]ethyl]-5-methyl-1,2-benzisoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: 515138-49-5
6-acetamido-3,5-dimethyl-1,2-benzisoxazole

: 726174-61-4
5-chloromethyl-4-isopropyl-2-[4-(trifluoromethyl)phenyl]thiazole

: 515138-35-9
6-acetamido-3-[2-[4-isopropyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl]ethyl]-5-methyl-1,2-benzisoxazole

Guidance literature:: 6-acetamido-3,5-dimethyl-1,2-benzisoxazole; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 0.916667h; Inert atmosphere;

5-chloromethyl-4-isopropyl-2-[4-(trifluoromethyl)phenyl]thiazole; In tetrahydrofuran; at -78 - 20 ℃; Inert atmosphere;
DOI:10.1016/j.bmc.2011.03.053

Reference yield:

: 591774-94-6
methyl 4-isopropyl-2-[4-(trifluoromethyl) phenyl]thiazole-5-carboxylate

: 515138-35-9
6-acetamido-3-[2-[4-isopropyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl]ethyl]-5-methyl-1,2-benzisoxazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 2 h / 0 °C

2.1: thionyl chloride / benzene / 20.5 h / 0 - 20 °C

3.1: lithium diisopropyl amide / tetrahydrofuran / 0.92 h / -78 °C / Inert atmosphere

3.2: -78 - 20 °C / Inert atmosphere

With thionyl chloride; sodium bis(2-methoxyethoxy)aluminium dihydride; lithium diisopropyl amide; In tetrahydrofuran; toluene; benzene;
DOI:10.1016/j.bmc.2011.03.053

Reference yield:

: 592519-45-4
4-isopropyl-2-[4-(trifluoromethyl)phenyl]thiazole-5-methanol

: 515138-35-9
6-acetamido-3-[2-[4-isopropyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl]ethyl]-5-methyl-1,2-benzisoxazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: thionyl chloride / benzene / 20.5 h / 0 - 20 °C

2.1: lithium diisopropyl amide / tetrahydrofuran / 0.92 h / -78 °C / Inert atmosphere

2.2: -78 - 20 °C / Inert atmosphere

With thionyl chloride; lithium diisopropyl amide; In tetrahydrofuran; benzene;
DOI:10.1016/j.bmc.2011.03.053