6-amino-3-[2-[4-isopropyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl]ethyl]-5-methyl-1,2-benzisoxazole

Base Information

Chemical Name:6-amino-3-[2-[4-isopropyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl]ethyl]-5-methyl-1,2-benzisoxazole
CAS No.:515138-36-0
Molecular Formula:C₂₃H₂₂F₃N₃OS
Molecular Weight:445.508
Hs Code.:

Synonyms:6-amino-3-[2-[4-isopropyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl]ethyl]-5-methyl-1,2-benzisoxazole

Suppliers and Price of 6-amino-3-[2-[4-isopropyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl]ethyl]-5-methyl-1,2-benzisoxazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 6-amino-3-[2-[4-isopropyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl]ethyl]-5-methyl-1,2-benzisoxazole

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 6-amino-3-[2-[4-isopropyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl]ethyl]-5-methyl-1,2-benzisoxazole

There total 7 articles about 6-amino-3-[2-[4-isopropyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl]ethyl]-5-methyl-1,2-benzisoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 515138-35-9
6-acetamido-3-[2-[4-isopropyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl]ethyl]-5-methyl-1,2-benzisoxazole

: 515138-36-0
6-amino-3-[2-[4-isopropyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl]ethyl]-5-methyl-1,2-benzisoxazole

Guidance literature:: 6-acetamido-3-[2-[4-isopropyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl]ethyl]-5-methyl-1,2-benzisoxazole; With hydrogenchloride; water; acetic acid; for 24h; Reflux;

With sodium hydroxide; In water; Cooling with ice;
DOI:10.1016/j.bmc.2011.03.053

Reference yield:

: 515138-49-5
6-acetamido-3,5-dimethyl-1,2-benzisoxazole

: 515138-36-0
6-amino-3-[2-[4-isopropyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl]ethyl]-5-methyl-1,2-benzisoxazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 0.92 h / -78 °C / Inert atmosphere

1.2: -78 - 20 °C / Inert atmosphere

2.1: hydrogenchloride; water; acetic acid / 24 h / Reflux

2.2: Cooling with ice

With hydrogenchloride; water; acetic acid; lithium diisopropyl amide; In tetrahydrofuran;
DOI:10.1016/j.bmc.2011.03.053

Reference yield:

: 591774-94-6
methyl 4-isopropyl-2-[4-(trifluoromethyl) phenyl]thiazole-5-carboxylate

: 515138-36-0
6-amino-3-[2-[4-isopropyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl]ethyl]-5-methyl-1,2-benzisoxazole

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 2 h / 0 °C

2.1: thionyl chloride / benzene / 20.5 h / 0 - 20 °C

3.1: lithium diisopropyl amide / tetrahydrofuran / 0.92 h / -78 °C / Inert atmosphere

3.2: -78 - 20 °C / Inert atmosphere

4.1: hydrogenchloride; water; acetic acid / 24 h / Reflux

4.2: Cooling with ice

With hydrogenchloride; thionyl chloride; water; acetic acid; sodium bis(2-methoxyethoxy)aluminium dihydride; lithium diisopropyl amide; In tetrahydrofuran; toluene; benzene;
DOI:10.1016/j.bmc.2011.03.053