4-dimethylamino-3-(2-hydroxyethyl)-N-methoxy-N-methylbenzamide

Base Information

• Chemical Name: 4-dimethylamino-3-(2-hydroxyethyl)-N-methoxy-N-methylbenzamide
• CAS No.: 1243248-41-0
• Molecular Formula: C₁₃H₂₀N₂O₃
• Molecular Weight: 252.313
• Mol file: 1243248-41-0.mol

Synonyms:4-dimethylamino-3-(2-hydroxyethyl)-N-methoxy-N-methylbenzamide

Chemical Property of 4-dimethylamino-3-(2-hydroxyethyl)-N-methoxy-N-methylbenzamide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 4-dimethylamino-3-(2-hydroxyethyl)-N-methoxy-N-methylbenzamide

There total 1 articles about 4-dimethylamino-3-(2-hydroxyethyl)-N-methoxy-N-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 3-(2-hydroxyethyl)-N-methoxy-N-methyl-4-nitrobenzamide (1243248-40-9) → 4-dimethylamino-3-(2-hydroxyethyl)-N-methoxy-N-methylbenzamide (1243248-41-0)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethanol; water;

DOI:10.1002/asia.201000058

Reference yield: 67.0%

4-dimethylamino-3-(2-hydroxyethyl)-N-methoxy-N-methylbenzamide (1243248-41-0) → 4-(dimethylamino)-3-(2-hydroxyethyl) benzaldehyde (1243248-36-3)

Guidance literature:

With diisobutylaluminium hydride; In tetrahydrofuran; at -78 ℃; Inert atmosphere;

DOI:10.1002/asia.201000058

Reference yield:

4-dimethylamino-3-(2-hydroxyethyl)-N-methoxy-N-methylbenzamide (1243248-41-0) → (E)-4-(4-dimethylamino-3-(2-hydroxyethyl)styryl)-1-methylpyridinium iodide (1243248-27-2)

Guidance literature:

Multi-step reaction with 2 steps

1: diisobutylaluminium hydride / tetrahydrofuran / -78 °C / Inert atmosphere

2: triethylamine / methanol / 24 h / Reflux

With diisobutylaluminium hydride; triethylamine; In tetrahydrofuran; methanol;

DOI:10.1002/asia.201000058

upstream raw materials:

formaldehyd

3-(2-hydroxyethyl)-N-methoxy-N-methyl-4-nitrobenzamide

Downstream raw materials:

4-(dimethylamino)-3-(2-hydroxyethyl) benzaldehyde

(E)-2-(2-dimethylamino-5-(4-nitrostyryl)phenyl)ethanol

(E)-4-(4-dimethylamino-3-(2-hydroxyethyl)styryl)-1-methylpyridinium iodide

(E)-4-(4-dimethylamino-3-(2-hydroxyethyl)styryl)benzonitrile