Cyclooctanecarboxylic acid, 2-amino-, ethyl ester, (1R,2S)- (9CI)

Base Information

Chemical Name:Cyclooctanecarboxylic acid, 2-amino-, ethyl ester, (1R,2S)- (9CI)
CAS No.:772330-11-7
Molecular Formula:C₁₁H₂₁NO₂
Molecular Weight:199.293
Hs Code.:
Mol file:772330-11-7.mol

Synonyms:Cyclooctanecarboxylic acid, 2-amino-, ethyl ester, (1R,2S)- (9CI)

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Cyclooctanecarboxylic acid, 2-amino-, ethyl ester, (1R,2S)- (9CI)

Chemical Property:

Boiling Point:276.2±33.0 °C(Predicted)
PKA:10.38±0.40(Predicted)
Density:0.978±0.06 g/cm3(Predicted)

Purity/Quality:

Safty Information:

Pictogram(s):
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MSDS Files:

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Technology Process of Cyclooctanecarboxylic acid, 2-amino-, ethyl ester, (1R,2S)- (9CI)

There total 9 articles about Cyclooctanecarboxylic acid, 2-amino-, ethyl ester, (1R,2S)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: ethyl trans-2-azidocyclooctanecarboxylate

: 772330-11-7,758676-44-7
ethyl trans-2-aminocyclooctanecarboxylate

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate; at 20 ℃; for 2h;
DOI:10.1055/s-2005-861875

Reference yield:

: (1R,2R)-ethyl 2-azidocyclooctanecarboxylate

: 772330-11-7,758676-44-7
(1R,2R)-ethyl 2-aminocyclooctanecarboxylate

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate; at 20 ℃; for 2h;
DOI:10.1055/s-2005-861875

Reference yield:

: (1R,2S)-ethyl 2-tosyloxycyclooctanecarboxylate

: 772330-11-7,758676-44-7
(1R,2R)-ethyl 2-aminocyclooctanecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: NaN₃; tetrabutylammonium bromide / dimethylformamide / 16 h / 20 °C

2: H₂ / Pd/C / ethyl acetate / 2 h / 20 °C

With sodium azide; tetrabutylammomium bromide; hydrogen; palladium on activated charcoal; In ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1055/s-2005-861875