2-(1-(2-(2-(methylsulfonyl)phenyl)-1,5-naphthyridin-3-yl)ethyl)isoindoline-1,3-dione

Base Information

Chemical Name:2-(1-(2-(2-(methylsulfonyl)phenyl)-1,5-naphthyridin-3-yl)ethyl)isoindoline-1,3-dione
CAS No.:1312606-02-2
Molecular Formula:C₂₅H₁₉N₃O₄S
Molecular Weight:457.51
Hs Code.:

Synonyms:2-(1-(2-(2-(methylsulfonyl)phenyl)-1,5-naphthyridin-3-yl)ethyl)isoindoline-1,3-dione

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Chemical Property of 2-(1-(2-(2-(methylsulfonyl)phenyl)-1,5-naphthyridin-3-yl)ethyl)isoindoline-1,3-dione

Chemical Property:

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Technology Process of 2-(1-(2-(2-(methylsulfonyl)phenyl)-1,5-naphthyridin-3-yl)ethyl)isoindoline-1,3-dione

There total 11 articles about 2-(1-(2-(2-(methylsulfonyl)phenyl)-1,5-naphthyridin-3-yl)ethyl)isoindoline-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 136918-14-4,85-41-6
phthalimide

: 1312606-01-1
methyl (2-(2-(methylsulfonyl)phenyl)-1,5-naphthyridin-3-yl)methanol

: 1312606-02-2
2-(1-(2-(2-(methylsulfonyl)phenyl)-1,5-naphthyridin-3-yl)ethyl)isoindoline-1,3-dione

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 ℃;

Reference yield:

: 5470-18-8,34515-82-7
2-Chloro-3-nitropyridine

: 1312606-02-2
2-(1-(2-(2-(methylsulfonyl)phenyl)-1,5-naphthyridin-3-yl)ethyl)isoindoline-1,3-dione

Guidance literature:: Multi-step reaction with 8 steps

1: bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 110 °C / Inert atmosphere

2: osmium(VIII) oxide; water; 4-methylmorpholine N-oxide / tetrahydrofuran / 5 h / 25 °C

3: hydrogen / palladium on carbon / ethanol / Inert atmosphere

4: cerium(III) chloride heptahydrate / 3 h / 100 °C

5: diisobutylaluminium hydride / dichloromethane / 4 h / -78 °C

6: dipyridinium dichromate / dichloromethane / 25 °C

7: tetrahydrofuran / 2 h / 0 °C

8: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0 °C

With osmium(VIII) oxide; dipyridinium dichromate; cerium(III) chloride heptahydrate; di-isopropyl azodicarboxylate; water; hydrogen; diisobutylaluminium hydride; 4-methylmorpholine N-oxide; triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride; palladium on carbon; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane;

Reference yield:

: 150281-83-7
2-ethenyl-3-nitropyridine

: 1312606-02-2
2-(1-(2-(2-(methylsulfonyl)phenyl)-1,5-naphthyridin-3-yl)ethyl)isoindoline-1,3-dione

Guidance literature:: Multi-step reaction with 7 steps

1: osmium(VIII) oxide; water; 4-methylmorpholine N-oxide / tetrahydrofuran / 5 h / 25 °C

2: hydrogen / palladium on carbon / ethanol / Inert atmosphere

3: cerium(III) chloride heptahydrate / 3 h / 100 °C

4: diisobutylaluminium hydride / dichloromethane / 4 h / -78 °C

5: dipyridinium dichromate / dichloromethane / 25 °C

6: tetrahydrofuran / 2 h / 0 °C

7: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0 °C

With osmium(VIII) oxide; dipyridinium dichromate; cerium(III) chloride heptahydrate; di-isopropyl azodicarboxylate; water; hydrogen; diisobutylaluminium hydride; 4-methylmorpholine N-oxide; triphenylphosphine; palladium on carbon; In tetrahydrofuran; ethanol; dichloromethane;