(2E)-3-chloro-2-(3,4-dimethoxyphenyl)-3-(2-thienyl)acrylaldehyde

Base Information

• Chemical Name: (2E)-3-chloro-2-(3,4-dimethoxyphenyl)-3-(2-thienyl)acrylaldehyde
• CAS No.: 1579295-74-1
• Molecular Formula: C₁₅H₁₃ClO₃S
• Molecular Weight: 308.785
• Mol file: 1579295-74-1.mol

Synonyms:(2E)-3-chloro-2-(3,4-dimethoxyphenyl)-3-(2-thienyl)acrylaldehyde

Chemical Property of (2E)-3-chloro-2-(3,4-dimethoxyphenyl)-3-(2-thienyl)acrylaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2E)-3-chloro-2-(3,4-dimethoxyphenyl)-3-(2-thienyl)acrylaldehyde

There total 2 articles about (2E)-3-chloro-2-(3,4-dimethoxyphenyl)-3-(2-thienyl)acrylaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N,N-dimethyl-formamide (68-12-2,33513-42-7) + 2-(3,4-dimethoxyphenyl)-1-(thiophen-2-yl)ethan-1-one (214831-33-1) → (2E)-3-chloro-2-(3,4-dimethoxyphenyl)-3-(2-thienyl)acrylaldehyde (1579295-74-1) + (2Z)-3-chloro-2-(3,4-dimethoxyphenyl)-3-(2-thienyl)acrylaldehyde (1579295-70-7)

Guidance literature:

N,N-dimethyl-formamide; With trichlorophosphate; at 0 ℃; for 0.5h;

2-(3,4-dimethoxyphenyl)-1-(thiophen-2-yl)ethan-1-one; at 60 - 65 ℃; for 5h; Overall yield = 78 %; Overall yield = 1.42 g;

DOI:10.1021/ol500356w

Reference yield:

(3,4-Dimethoxyphenyl)acetic acid (93-40-3) → (2E)-3-chloro-2-(3,4-dimethoxyphenyl)-3-(2-thienyl)acrylaldehyde (1579295-74-1) + (2Z)-3-chloro-2-(3,4-dimethoxyphenyl)-3-(2-thienyl)acrylaldehyde (1579295-70-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: trifluoroacetic anhydride; phosphoric acid / acetonitrile / 3 h / 50 °C

2.1: trichlorophosphate / 0.5 h / 0 °C

2.2: 5 h / 60 - 65 °C

With phosphoric acid; trifluoroacetic anhydride; trichlorophosphate; In acetonitrile; 2.1: |Vilsmeier-Haack Formylation / 2.2: |Vilsmeier-Haack Formylation;

DOI:10.1021/ol500356w

upstream raw materials:

N,N-dimethyl-formamide

2-(3,4-dimethoxyphenyl)-1-(thiophen-2-yl)ethan-1-one

(3,4-Dimethoxyphenyl)acetic acid