N-((4-fluorophenyl)ethynyl)-N-methylmethanesulfonamide

Base Information

• Chemical Name: N-((4-fluorophenyl)ethynyl)-N-methylmethanesulfonamide
• CAS No.: 1333483-15-0
• Molecular Formula: C₁₀H₁₀FNO₂S
• Molecular Weight: 227.259
• Mol file: 1333483-15-0.mol

Synonyms:N-((4-fluorophenyl)ethynyl)-N-methylmethanesulfonamide

Chemical Property of N-((4-fluorophenyl)ethynyl)-N-methylmethanesulfonamide

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of N-((4-fluorophenyl)ethynyl)-N-methylmethanesulfonamide

There total 1 articles about N-((4-fluorophenyl)ethynyl)-N-methylmethanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

N-methylmethane sulphonamide (1184-85-6) + 1-(bromoethynyl)-4-fluorobenzene (95895-33-3) → N-((4-fluorophenyl)ethynyl)-N-methylmethanesulfonamide (1333483-15-0)

Guidance literature:

With 1,10-Phenanthroline; copper(ll) sulfate pentahydrate; potassium carbonate; In toluene; at 80 ℃; for 12h; Inert atmosphere;

DOI:10.1039/c6cc02776h

Reference yield: 95.0%

N-((4-fluorophenyl)ethynyl)-N-methylmethanesulfonamide (1333483-15-0) → C10H11F2NO2S

Guidance literature:

With water; silver fluoride; In acetonitrile; at 80 ℃; for 5h; stereoselective reaction;

DOI:10.1016/j.tetlet.2014.09.072

Reference yield: 94.0%

N-tert-pentanoyloxy-p-methoxybenzamide (1293990-75-6) + N-((4-fluorophenyl)ethynyl)-N-methylmethanesulfonamide (1333483-15-0) → N-(4-(4-fluorophenyl)-2-(4-methoxyphenyl)oxazol-5-yl)-N-methylmethanesulfonamide

Guidance literature:

With carbonyl(pentamethylcyclopentadienyl)cobalt diiodide; sodium acetate; In 2,2,2-trifluoroethanol; at 25 ℃; regioselective reaction; Schlenk technique;

DOI:10.1021/acs.orglett.7b02959

upstream raw materials:

N-methylmethane sulphonamide

1-(bromoethynyl)-4-fluorobenzene

Downstream raw materials:

1-(4-fluorophenyl)-2-(phenylamino)ethan-1-ol

2-(4'-fluorophenyl)-2-(phenylamino)ethanol

2-(4-fluorophenyl)-N-methyl-N-(methylsulfonyl)-2-(phenylamino)acetamide

N-(6-fluoro-4-(4-methoxyphenyl)-3,4-dihydronaphthalen-2-yl)-N-methylmethanesulfonamide