2-[4-(Difluoromethoxy)phenyl]ethanamine

Base Information

Chemical Name:2-[4-(Difluoromethoxy)phenyl]ethanamine
CAS No.:771581-14-7
Molecular Formula:C9H11 F2 N O
Molecular Weight:187.189
Hs Code.:2922199090
European Community (EC) Number:850-962-8
DSSTox Substance ID:DTXSID40407054
Wikidata:Q82212278
Mol file:771581-14-7.mol

Synonyms:2-[4-(difluoromethoxy)phenyl]ethanamine;771581-14-7;2-[4-(difluoromethoxy)phenyl]ethan-1-amine;Benzeneethanamine,4-(difluoromethoxy)-;2-(4-(DIFLUOROMETHOXY)PHENYL)ETHAN-1-AMINE;SCHEMBL3640668;DTXSID40407054;HMS1719G02;MFCD06212915;AKOS000200577;AT28726;NCGC00335022-01;BS-13738;EN300-13202;AB01327003-02

Suppliers and Price of 2-[4-(Difluoromethoxy)phenyl]ethanamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
2-[4-(DIFLUOROMETHOXY)PHENYL]ETHANAMINE 95.00%
5G
$ 1928.08

American Custom Chemicals Corporation
2-[4-(DIFLUOROMETHOXY)PHENYL]ETHANAMINE 95.00%
2.5G
$ 1473.14

American Custom Chemicals Corporation
2-[4-(DIFLUOROMETHOXY)PHENYL]ETHANAMINE 95.00%
1G
$ 983.52

AK Scientific
2-[4-(Difluoromethoxy)phenyl]ethanamine
500mg
$ 692.00

Total 4 raw suppliers

Chemical Property of 2-[4-(Difluoromethoxy)phenyl]ethanamine

Chemical Property:

Boiling Point:244.3±35.0 °C(Predicted)
PKA:9.73±0.10(Predicted)
PSA：35.25000
Density:1.161±0.06 g/cm3(Predicted)
LogP:2.48950
XLogP3:2.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:187.08087030
Heavy Atom Count:13
Complexity:136

Purity/Quality:

98% ^*data from raw suppliers

2-[4-(DIFLUOROMETHOXY)PHENYL]ETHANAMINE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=CC=C1CCN)OC(F)F

Technology Process of 2-[4-(Difluoromethoxy)phenyl]ethanamine

There total 1 articles about 2-[4-(Difluoromethoxy)phenyl]ethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-(4-(difluoromethoxy)phenyl)acetonitrile

: 771581-14-7
2-[4-(difluoromethoxy)phenyl]ethanamine

Guidance literature:: 2-(4-(difluoromethoxy)phenyl)acetonitrile; With borane-THF; In tetrahydrofuran; at 0 - 20 ℃; for 21.75h; Heating / reflux;

With methanol; In tetrahydrofuran; at 0 - 5 ℃; for 1.4h; Heating / reflux;

Reference yield:

: 3638-04-8
2,4-Dichloro-6-methoxy-1,3,5-triazine

: 771581-14-7
2-[4-(difluoromethoxy)phenyl]ethanamine

: 1443151-81-2
4-chloro-N-{2-[4-(difluoromethoxy)phenyl]ethyl}-6-methoxy-1,3,5-triazin-2-amine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In acetonitrile; for 0.5h; Cooling with ice;

Reference yield:

: 771581-14-7
2-[4-(difluoromethoxy)phenyl]ethanamine

: 1443151-54-9
2-{2-chloro-5-[4-({2-[4-(difluoromethoxy)phenyl]ethyl}amino)-6-methoxy-1,3,5-triazin-2-yl]phenyl}propan-2-ol

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / acetonitrile / 0.5 h / Cooling with ice

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / water; 1,2-dimethoxyethane / 48 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; N-ethyl-N,N-diisopropylamine; In 1,2-dimethoxyethane; water; acetonitrile;