Technology Process of 4-(7,7,10,10-Tetramethyl-2,5-dioxo-1,2,3,5,7,8,9,10-octahydro-naphtho[2,3-e][1,4]diazepin-4-yl)-benzoic acid methyl ester
There total 6 articles about 4-(7,7,10,10-Tetramethyl-2,5-dioxo-1,2,3,5,7,8,9,10-octahydro-naphtho[2,3-e][1,4]diazepin-4-yl)-benzoic acid methyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
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155877-94-4
4-(7,7,10,10-Tetramethyl-2,5-dioxo-1,2,3,5,7,8,9,10-octahydro-naphtho[2,3-e][1,4]diazepin-4-yl)-benzoic acid methyl ester
- Guidance literature:
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With
potassium carbonate; methylamine;
In
2-methoxy-ethanol;
at 80 ℃;
for 2.5h;
DOI:10.1021/jm00036a017
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155877-94-4
4-(7,7,10,10-Tetramethyl-2,5-dioxo-1,2,3,5,7,8,9,10-octahydro-naphtho[2,3-e][1,4]diazepin-4-yl)-benzoic acid methyl ester
- Guidance literature:
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Multi-step reaction with 6 steps
1: 69 percent / HNO3, H2SO4 / 1 h / Ambient temperature
2: thionyl chloride / 2 h / 55 °C
3: pyridine / diethyl ether
4: 74 percent / Fe, aq. NH4Cl / methanol / 3.5 h / Heating
5: 70 percent / pyridine / diethyl ether / 5 h / Ambient temperature
6: 89 percent / methylamine, K2CO3 / 2-methoxy-ethanol / 2.5 h / 80 °C
With
pyridine; thionyl chloride; sulfuric acid; nitric acid; iron; potassium carbonate; ammonium chloride; methylamine;
In
methanol; diethyl ether; 2-methoxy-ethanol;
DOI:10.1021/jm00036a017
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-
155877-94-4
4-(7,7,10,10-Tetramethyl-2,5-dioxo-1,2,3,5,7,8,9,10-octahydro-naphtho[2,3-e][1,4]diazepin-4-yl)-benzoic acid methyl ester
- Guidance literature:
-
Multi-step reaction with 4 steps
1: pyridine / diethyl ether
2: 74 percent / Fe, aq. NH4Cl / methanol / 3.5 h / Heating
3: 70 percent / pyridine / diethyl ether / 5 h / Ambient temperature
4: 89 percent / methylamine, K2CO3 / 2-methoxy-ethanol / 2.5 h / 80 °C
With
pyridine; iron; potassium carbonate; ammonium chloride; methylamine;
In
methanol; diethyl ether; 2-methoxy-ethanol;
DOI:10.1021/jm00036a017