α-(2-chloro-4-fluorophenyl)-2-methyl-1-(2,4,6-trifluorophenyl)-1H-imidazole-5-methanol

Base Information

Chemical Name:α-(2-chloro-4-fluorophenyl)-2-methyl-1-(2,4,6-trifluorophenyl)-1H-imidazole-5-methanol
CAS No.:1369394-47-7
Molecular Formula:C₁₇H₁₁ClF₄N₂O
Molecular Weight:370.734
Hs Code.:

Synonyms:α-(2-chloro-4-fluorophenyl)-2-methyl-1-(2,4,6-trifluorophenyl)-1H-imidazole-5-methanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of α-(2-chloro-4-fluorophenyl)-2-methyl-1-(2,4,6-trifluorophenyl)-1H-imidazole-5-methanol

Chemical Property:

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Technology Process of α-(2-chloro-4-fluorophenyl)-2-methyl-1-(2,4,6-trifluorophenyl)-1H-imidazole-5-methanol

There total 3 articles about α-(2-chloro-4-fluorophenyl)-2-methyl-1-(2,4,6-trifluorophenyl)-1H-imidazole-5-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 110407-59-5
1-bromo-2-chloro-4-fluorobenzene

: 1369399-09-6
2-methyl-1-(2,4,6-trifluorophenyl)-1H-imidazole-5-carboxaldehyde

: 1369394-47-7
α-(2-chloro-4-fluorophenyl)-2-methyl-1-(2,4,6-trifluorophenyl)-1H-imidazole-5-methanol

Guidance literature:: 1-bromo-2-chloro-4-fluorobenzene; With TurboGrignard; In tetrahydrofuran; at -3 - 5 ℃; for 1.66667h;

2-methyl-1-(2,4,6-trifluorophenyl)-1H-imidazole-5-carboxaldehyde; In tetrahydrofuran; at 0 - 5 ℃; for 1.16667h;

With ammonium chloride; In tetrahydrofuran; water;

Reference yield:

: 363-81-5
2,4,6-trifluoroaniline

: 1369394-47-7
α-(2-chloro-4-fluorophenyl)-2-methyl-1-(2,4,6-trifluorophenyl)-1H-imidazole-5-methanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride / 16 h / 20 °C

2.1: acetic acid; triethylamine / isopropyl alcohol / 1 h / Reflux

3.1: TurboGrignard / tetrahydrofuran / 1.67 h / -3 - 5 °C

3.2: 1.17 h / 0 - 5 °C

With hydrogenchloride; TurboGrignard; acetic acid; triethylamine; In tetrahydrofuran; isopropyl alcohol;

Reference yield:

: 1369399-08-5
N-(2,4,6-trifluorophenyl)ethanimidamide

: 1369394-47-7
α-(2-chloro-4-fluorophenyl)-2-methyl-1-(2,4,6-trifluorophenyl)-1H-imidazole-5-methanol

Guidance literature:: Multi-step reaction with 2 steps

1.1: acetic acid; triethylamine / isopropyl alcohol / 1 h / Reflux

2.1: TurboGrignard / tetrahydrofuran / 1.67 h / -3 - 5 °C

2.2: 1.17 h / 0 - 5 °C

With TurboGrignard; acetic acid; triethylamine; In tetrahydrofuran; isopropyl alcohol;