(2S,3S,4R)-4-(9H-fluoren-9-ylmethoxycarbonylamino)-3-hydroxy-2-methyl-5-phenylpentanoic acid

Base Information

Chemical Name:(2S,3S,4R)-4-(9H-fluoren-9-ylmethoxycarbonylamino)-3-hydroxy-2-methyl-5-phenylpentanoic acid
CAS No.:574012-10-5
Molecular Formula:C₂₇H₂₇NO₅
Molecular Weight:445.515
Hs Code.:

Synonyms:(2S,3S,4R)-4-(9H-fluoren-9-ylmethoxycarbonylamino)-3-hydroxy-2-methyl-5-phenylpentanoic acid

Suppliers and Price of (2S,3S,4R)-4-(9H-fluoren-9-ylmethoxycarbonylamino)-3-hydroxy-2-methyl-5-phenylpentanoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2S,3S,4R)-4-(9H-fluoren-9-ylmethoxycarbonylamino)-3-hydroxy-2-methyl-5-phenylpentanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2S,3S,4R)-4-(9H-fluoren-9-ylmethoxycarbonylamino)-3-hydroxy-2-methyl-5-phenylpentanoic acid

There total 6 articles about (2S,3S,4R)-4-(9H-fluoren-9-ylmethoxycarbonylamino)-3-hydroxy-2-methyl-5-phenylpentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 77119-85-8
N-(tert-butoxycarbonyl)-D-phenylalaninal

: 574012-10-5
(2S,3S,4R)-4-(9H-fluoren-9-ylmethoxycarbonylamino)-3-hydroxy-2-methyl-5-phenylpentanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: Bu₂BOTf; iPr₂NEt / CH₂Cl₂ / 1 h

1.2: CH₂Cl₂ / -78 - 20 °C

1.3: 3.7 g / aq. H₂O₂ / methanol / 4 h

2.1: 87 percent / aq. H₂O₂; aq. LiOH / tetrahydrofuran / 3 h / 0 °C

3.1: TFA; Me₂S / 2 h

4.1: 657 mg / aq. K₂CO₃ / dioxane / 16 h

With lithium hydroxide; dimethylsulfide; di-n-butylboryl trifluoromethanesulfonate; dihydrogen peroxide; potassium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; dichloromethane;
DOI:10.1021/ja021388w

Reference yield:

: 574012-08-1
(2S,3S,4R)-4-tert-butoxycarbonylamino-3-hydroxy-2-methyl-5-phenyl-pentanoic acid

: 574012-10-5
(2S,3S,4R)-4-(9H-fluoren-9-ylmethoxycarbonylamino)-3-hydroxy-2-methyl-5-phenylpentanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: TFA; Me₂S / 2 h

2: 657 mg / aq. K₂CO₃ / dioxane / 16 h

With dimethylsulfide; potassium carbonate; trifluoroacetic acid; In 1,4-dioxane;
DOI:10.1021/ja021388w

Reference yield:

: 574012-06-9
(1R,2S,3S,4'S)-[1-benzyl-2-hydroxy-4-(4'-isopropyl-2'-oxo-oxazolidin-3'-yl)-3-methyl-4-oxobutyl]carbamic acid tert-butyl ester

: 574012-10-5
(2S,3S,4R)-4-(9H-fluoren-9-ylmethoxycarbonylamino)-3-hydroxy-2-methyl-5-phenylpentanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 87 percent / aq. H₂O₂; aq. LiOH / tetrahydrofuran / 3 h / 0 °C

2: TFA; Me₂S / 2 h

3: 657 mg / aq. K₂CO₃ / dioxane / 16 h

With lithium hydroxide; dimethylsulfide; dihydrogen peroxide; potassium carbonate; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane;
DOI:10.1021/ja021388w