4-fluoro-3-[[2-fluoro-5-(3-fluorophenyl)phenyl]methylamino]-2-methyl-phenol

Base Information

Chemical Name:4-fluoro-3-[[2-fluoro-5-(3-fluorophenyl)phenyl]methylamino]-2-methyl-phenol
CAS No.:1427407-18-8
Molecular Formula:C₂₀H₁₆F₃NO
Molecular Weight:343.348
Hs Code.:

Synonyms:4-fluoro-3-[[2-fluoro-5-(3-fluorophenyl)phenyl]methylamino]-2-methyl-phenol

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Chemical Property of 4-fluoro-3-[[2-fluoro-5-(3-fluorophenyl)phenyl]methylamino]-2-methyl-phenol

Chemical Property:

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Technology Process of 4-fluoro-3-[[2-fluoro-5-(3-fluorophenyl)phenyl]methylamino]-2-methyl-phenol

There total 12 articles about 4-fluoro-3-[[2-fluoro-5-(3-fluorophenyl)phenyl]methylamino]-2-methyl-phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 1427407-17-7
2-fluoro-N-(6-fluoro-3-hydroxy-2-methyl-phenyl)-5-(3-fluorophenyl)benzamide

: 1427407-18-8
4-fluoro-3-[[2-fluoro-5-(3-fluorophenyl)phenyl]methylamino]-2-methyl-phenol

Guidance literature:: With borane-THF; In tetrahydrofuran; at 50 ℃; Inert atmosphere;

Reference yield:

: 1214382-15-6
C₁₃H₇ClF₂O

: 1427407-18-8
4-fluoro-3-[[2-fluoro-5-(3-fluorophenyl)phenyl]methylamino]-2-methyl-phenol

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran / 2 h / 0 - 20 °C

2: borane-THF / tetrahydrofuran / 50 °C / Inert atmosphere

With borane-THF; In tetrahydrofuran;

Reference yield:

: 3013-27-2
1-fluoro-3-methyl-2-nitro-benzene

: 1427407-18-8
4-fluoro-3-[[2-fluoro-5-(3-fluorophenyl)phenyl]methylamino]-2-methyl-phenol

Guidance literature:: Multi-step reaction with 8 steps

1: sulfuric acid; N-Bromosuccinimide / 2 h / 20 °C

2: iron; ammonium chloride / ethanol / 3 h / Reflux

3: dmap; triethylamine / N,N-dimethyl-formamide

4: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 4 h / 80 °C / Inert atmosphere

5: dihydrogen peroxide; water; sodium hydroxide / tetrahydrofuran / 3 h / 0 - 20 °C

6: trifluoroacetic acid / dichloromethane / 20 °C

7: tetrahydrofuran / 2 h / 0 - 20 °C

8: borane-THF / tetrahydrofuran / 50 °C / Inert atmosphere

With dmap; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-Bromosuccinimide; borane-THF; sulfuric acid; water; dihydrogen peroxide; potassium acetate; iron; ammonium chloride; triethylamine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;