methyl 6-(4-fluorophenyl)-2-methoxy-4-methyl-1,6-dihydro-5-pyrimidinecarboxylate

Base Information

Chemical Name:methyl 6-(4-fluorophenyl)-2-methoxy-4-methyl-1,6-dihydro-5-pyrimidinecarboxylate
CAS No.:251930-53-7
Molecular Formula:C₁₄H₁₅FN₂O₃
Molecular Weight:278.283
Hs Code.:

Synonyms:methyl 6-(4-fluorophenyl)-2-methoxy-4-methyl-1,6-dihydro-5-pyrimidinecarboxylate

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Chemical Property of methyl 6-(4-fluorophenyl)-2-methoxy-4-methyl-1,6-dihydro-5-pyrimidinecarboxylate

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Technology Process of methyl 6-(4-fluorophenyl)-2-methoxy-4-methyl-1,6-dihydro-5-pyrimidinecarboxylate

There total 4 articles about methyl 6-(4-fluorophenyl)-2-methoxy-4-methyl-1,6-dihydro-5-pyrimidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.9%

: methyl (Z)-2-[(4'-fluorophenyl)methylene]-3-oxobutanoate

: 29427-58-5,24285-39-0
O-methylisourea hemisulfate

: 251930-53-7
methyl 6-(4-fluorophenyl)-2-methoxy-4-methyl-1,6-dihydro-5-pyrimidinecarboxylate

Guidance literature:: With sodium hydrogencarbonate; In ethanol; for 24h; Heating / reflux;

Reference yield:

: 29427-58-5,24285-39-0
O-methylisourea hemisulfate

: 111556-82-2
2-[1-(4-Fluoro-phenyl)-meth-(Z)-ylidene]-3-oxo-butyric acid methyl ester

: 251930-53-7
4-(4-fluoro-phenyl)-2-methoxy-6-methyl-1,4-dihydro-pyrimidine-5-carboxylic acid methyl ester

Guidance literature:: With sodium hydrogencarbonate; In N,N-dimethyl-formamide; at 70 ℃; for 16h;
DOI:10.1021/jm990200p

Reference yield:

: 459-57-4
4-fluorobenzaldehyde

: 251930-53-7
4-(4-fluoro-phenyl)-2-methoxy-6-methyl-1,4-dihydro-pyrimidine-5-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: piperidine; AcOH / benzene / 8 h / Heating

2: NaHCO₃ / dimethylformamide / 16 h / 70 °C

With piperidine; sodium hydrogencarbonate; acetic acid; In N,N-dimethyl-formamide; benzene; 1: Condensation / 2: Condensation;
DOI:10.1021/jm990200p