6-bromo-9H-pyrido[2,3-b]indole

Base Information

• Chemical Name: 6-bromo-9H-pyrido[2,3-b]indole
• CAS No.: 26066-88-6
• Molecular Formula: C₁₁H₇BrN₂
• Molecular Weight: 247.094
• European Community (EC) Number: 810-826-0
• Mol file: 26066-88-6.mol

Synonyms:6-bromo-9H-pyrido[2,3-b]indole;26066-88-6;9H-Pyrido[2,3-b]indole, 6-bromo-;SCHEMBL674822;XCNVELJEUIETFR-UHFFFAOYSA-N;BBA06688;MFCD18803940;AKOS025404858;AS-61009;CS-0150005;W18367

Chemical Property of 6-bromo-9H-pyrido[2,3-b]indole

Chemical Property:

• XLogP3: 3.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 245.97926
• Heavy Atom Count: 14
• Complexity: 221

Purity/Quality:

98% ^*data from raw suppliers

6-Bromo-9H-pyrido[2,3-b]indole 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC2=C(NC3=C2C=C(C=C3)Br)N=C1

Technology Process of 6-bromo-9H-pyrido[2,3-b]indole

There total 10 articles about 6-bromo-9H-pyrido[2,3-b]indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

α-carboline (244-76-8) → 6-bromo-9H-pyrido[2,3-b]indole (26066-88-6)

Guidance literature:

With N-Bromosuccinimide; In dichloromethane; at 20 ℃; Inert atmosphere;

Reference yield:

aniline (62-53-3) → 6-bromo-9H-pyrido[2,3-b]indole (26066-88-6)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium diacetate; triphenylphosphine; sodium t-butanolate / o-xylene / 3 h / 120 °C

2: N-Bromosuccinimide; acetic acid / N,N-dimethyl-formamide / 2 h / 20 °C

With N-Bromosuccinimide; palladium diacetate; acetic acid; triphenylphosphine; sodium t-butanolate; In o-xylene; N,N-dimethyl-formamide;

Reference yield:

3-chloro-N-phenyl-2-aminopyridine (6604-94-0) → 6-bromo-9H-pyrido[2,3-b]indole (26066-88-6)

Guidance literature:

Multi-step reaction with 2 steps

1: tricyclohexylphosphine tetrafluoroborate; potassium carbonate; palladium diacetate / N,N-dimethyl acetamide / 4 h / Inert atmosphere; Reflux

2: N-Bromosuccinimide / dichloromethane / 20 °C / Inert atmosphere

With N-Bromosuccinimide; palladium diacetate; potassium carbonate; tricyclohexylphosphine tetrafluoroborate; In dichloromethane; N,N-dimethyl acetamide;

upstream raw materials:

α-carboline

2-chloropyridine

1,2,3-Benzotriazole

1-(pyridin-2-yl)-1H-benzo[d][1,2,3]triazole