N'-[2-(4-chlorophenyl)ethanimidoyl]-2-phenylacetohydrazide

Base Information

• Chemical Name: N'-[2-(4-chlorophenyl)ethanimidoyl]-2-phenylacetohydrazide
• CAS No.: 1616422-59-3
• Molecular Formula: C₁₆H₁₆ClN₃O
• Molecular Weight: 301.776
• Mol file: 1616422-59-3.mol

Synonyms:N'-[2-(4-chlorophenyl)ethanimidoyl]-2-phenylacetohydrazide

Chemical Property of N'-[2-(4-chlorophenyl)ethanimidoyl]-2-phenylacetohydrazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N'-[2-(4-chlorophenyl)ethanimidoyl]-2-phenylacetohydrazide

There total 1 articles about N'-[2-(4-chlorophenyl)ethanimidoyl]-2-phenylacetohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

ethyl 2-(4-chlorophenyl)acetimidate hydrochloride (43002-66-0) + 2-phenylacetylhydrazine (937-39-3) → N'-[2-(4-chlorophenyl)ethanimidoyl]-2-phenylacetohydrazide (1616422-59-3)

Guidance literature:

ethyl 2-(4-chlorophenyl)acetimidate hydrochloride; With sodium ethanolate; In ethanol; at 0 ℃;

2-phenylacetylhydrazine; In ethanol; at 20 ℃;

DOI:10.1080/00397911.2014.895382

Reference yield: 76.0%

N'-[2-(4-chlorophenyl)ethanimidoyl]-2-phenylacetohydrazide (1616422-59-3) + 4-chlorobenzoylmethyl bromide (536-38-9) → N-[2-(4-chlorobenzyl)-4-(4-chlorophenyl)-1H-imidazol-1-yl]-2-phenylacetamide (1616422-73-1)

Guidance literature:

In acetonitrile; at 90 ℃; for 0.333333h; Concentration; Temperature; Microwave irradiation;

DOI:10.1080/00397911.2014.895382

Reference yield: 71.0%

N'-[2-(4-chlorophenyl)ethanimidoyl]-2-phenylacetohydrazide (1616422-59-3) + α-bromoacetophenone (70-11-1) → N-[2-(4-chlorobenzyl)-4-phenyl-1H-imidazol-1-yl]-2-phenylacetamide (1616422-66-2)

Guidance literature:

In acetonitrile; at 90 ℃; for 0.333333h; Concentration; Temperature; Microwave irradiation;

DOI:10.1080/00397911.2014.895382

upstream raw materials:

ethyl 2-(4-chlorophenyl)acetimidate hydrochloride

2-phenylacetylhydrazine

Downstream raw materials:

N-[2-(4-chlorobenzyl)-4-phenyl-1H-imidazol-1-yl]-2-phenylacetamide

N-[2-(4-chlorobenzyl)-4-(4-chlorophenyl)-1H-imidazol-1-yl]-2-phenylacetamide