(22E,24R)-1α,3β-bis<(tert-butyldimethylsilyl)oxy>-5α,8α-(3,5-dioxo-4-phenyl-1,2,4-triazolidin-1,2-diyl)-24-fluoro-6,22-ergostadien-25-ol

Base Information

Chemical Name:(22E,24R)-1α,3β-bis<(tert-butyldimethylsilyl)oxy>-5α,8α-(3,5-dioxo-4-phenyl-1,2,4-triazolidin-1,2-diyl)-24-fluoro-6,22-ergostadien-25-ol
CAS No.:147200-39-3
Molecular Formula:C₄₈H₇₆FN₃O₅Si₂
Molecular Weight:850.318
Hs Code.:

Synonyms:(22E,24R)-1α,3β-bis<(tert-butyldimethylsilyl)oxy>-5α,8α-(3,5-dioxo-4-phenyl-1,2,4-triazolidin-1,2-diyl)-24-fluoro-6,22-ergostadien-25-ol

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Chemical Property of (22E,24R)-1α,3β-bis<(tert-butyldimethylsilyl)oxy>-5α,8α-(3,5-dioxo-4-phenyl-1,2,4-triazolidin-1,2-diyl)-24-fluoro-6,22-ergostadien-25-ol

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Technology Process of (22E,24R)-1α,3β-bis<(tert-butyldimethylsilyl)oxy>-5α,8α-(3,5-dioxo-4-phenyl-1,2,4-triazolidin-1,2-diyl)-24-fluoro-6,22-ergostadien-25-ol

There total 1 articles about (22E,24R)-1α,3β-bis<(tert-butyldimethylsilyl)oxy>-5α,8α-(3,5-dioxo-4-phenyl-1,2,4-triazolidin-1,2-diyl)-24-fluoro-6,22-ergostadien-25-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 917-54-4
methyllithium

: ethyl (22E)-1α,3β-bis<(tert-butyldimethylsilyl)oxy>-5α,8α-(3,5-dioxo-4-phenyl-1,2,4-triazolidin-1,2-diyl)-24-fluoro-24-methylcholesta-6,22-dien-25-oate

: 147200-39-3
(22E,24R)-1α,3β-bis<(tert-butyldimethylsilyl)oxy>-5α,8α-(3,5-dioxo-4-phenyl-1,2,4-triazolidin-1,2-diyl)-24-fluoro-6,22-ergostadien-25-ol

: (22E,24S)-1α,3β-bis<(tert-butyldimethylsilyl)oxy>-5α,8α-(3,5-dioxo-4-phenyl-1,2,4-triazolidin-1,2-diyl)-24-fluoro-6,22-ergostadien-25-ol

Guidance literature:: In tetrahydrofuran; at -78 - -40 ℃; for 0.583333h;
DOI:10.1248/cpb.40.2932

Reference yield: 75.0%

: 147200-39-3
(22E,24R)-1α,3β-bis<(tert-butyldimethylsilyl)oxy>-5α,8α-(3,5-dioxo-4-phenyl-1,2,4-triazolidin-1,2-diyl)-24-fluoro-6,22-ergostadien-25-ol

: (22E,24R)-5α,8α-(3,5-dioxo-4-phenyl-1,2,4-triazolidine-1,2-diyl)-24-fluoro-6,22-ergostadiene-1α,3β,25-triol

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 75 ℃; for 3.5h;
DOI:10.1248/cpb.40.2932

Reference yield:

: 147200-39-3
(22E,24R)-1α,3β-bis<(tert-butyldimethylsilyl)oxy>-5α,8α-(3,5-dioxo-4-phenyl-1,2,4-triazolidin-1,2-diyl)-24-fluoro-6,22-ergostadien-25-ol

: 135776-86-2
(24S)-24-fluoro-1α,25-dihydroxyvitamin D₂

Guidance literature:: Multi-step reaction with 3 steps

1: 75 percent / tetrabutylammonium fluoride (TBAF) / tetrahydrofuran / 3.5 h / 75 °C

2: 74 percent / K₂CO₃ / dimethylsulfoxide / 22 h / 110 - 115 °C

3: 1.) THF-ether, irradition, 0 deg C, 5 min., 2.) ethanol, reflux, 1 h

With tetrabutyl ammonium fluoride; potassium carbonate; In tetrahydrofuran; dimethyl sulfoxide;
DOI:10.1248/cpb.40.2932