4-(2-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)-N-(1-oxidotetrahydro-2H-thiopyran-4-yl)benzenesulfonamide trifluoroacetate

Base Information

Chemical Name:4-(2-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)-N-(1-oxidotetrahydro-2H-thiopyran-4-yl)benzenesulfonamide trifluoroacetate
CAS No.:1187323-32-5
Molecular Formula:C₂HF₃O₂*C₁₉H₂₁N₃O₃S₂
Molecular Weight:517.55
Hs Code.:

Synonyms:4-(2-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)-N-(1-oxidotetrahydro-2H-thiopyran-4-yl)benzenesulfonamide trifluoroacetate

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Chemical Property of 4-(2-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)-N-(1-oxidotetrahydro-2H-thiopyran-4-yl)benzenesulfonamide trifluoroacetate

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Technology Process of 4-(2-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)-N-(1-oxidotetrahydro-2H-thiopyran-4-yl)benzenesulfonamide trifluoroacetate

There total 4 articles about 4-(2-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)-N-(1-oxidotetrahydro-2H-thiopyran-4-yl)benzenesulfonamide trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1014613-64-9
4-bromo-2-methyl-1H-pyrrolo[2,3-b]pyridine

: C₁₇H₂₆BNO₃S

: 76-05-1
trifluoroacetic acid

: 1187323-32-5
4-(2-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)-N-(1-oxidotetrahydro-2H-thiopyran-4-yl)benzenesulfonamide trifluoroacetate

Guidance literature:: 4-bromo-2-methyl-1H-pyrrolo[2,3-b]pyridine; C₁₇H₂₆BNO₃S; With potassium phosphate; 2’-(dimethylamino)-2-biphenylyl-palladium(II)chloride dinorbornylphosphine complex; In 1,4-dioxane; water; at 130 ℃; for 0.5h; Inert atmosphere; Microwave irradiation;

trifluoroacetic acid; In acetonitrile;

Reference yield:

: 1014613-05-8
1-(benzenesulfonyl)-4-bromo-2-methyl-1H-pyrrolo[2,3-b]pyridine

: 1187323-32-5
4-(2-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)-N-(1-oxidotetrahydro-2H-thiopyran-4-yl)benzenesulfonamide trifluoroacetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride; water / 1,4-dioxane / 16 h / 60 °C / Inert atmosphere

2.1: potassium phosphate / 2’-(dimethylamino)-2-biphenylyl-palladium(II)chloride dinorbornylphosphine complex / 1,4-dioxane; water / 0.5 h / 130 °C / Inert atmosphere; Microwave irradiation

2.2: C₁₈ cartridge

With hydrogenchloride; potassium phosphate; water; 2’-(dimethylamino)-2-biphenylyl-palladium(II)chloride dinorbornylphosphine complex; In 1,4-dioxane; water;

Reference yield:

: 889939-25-7
1-(benzenesulfonyl)-4-bromo-1H-pyrrolo[2,3-b]pyridine

: 1187323-32-5
4-(2-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)-N-(1-oxidotetrahydro-2H-thiopyran-4-yl)benzenesulfonamide trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium diisopropyl amide / tetrahydrofuran; n-heptane; ethylbenzene / 0.5 h / -35 °C / Inert atmosphere

1.2: 20 °C / Inert atmosphere

2.1: hydrogenchloride; water / 1,4-dioxane / 16 h / 60 °C / Inert atmosphere

3.1: potassium phosphate / 2’-(dimethylamino)-2-biphenylyl-palladium(II)chloride dinorbornylphosphine complex / 1,4-dioxane; water / 0.5 h / 130 °C / Inert atmosphere; Microwave irradiation

3.2: C₁₈ cartridge

With hydrogenchloride; potassium phosphate; water; lithium diisopropyl amide; 2’-(dimethylamino)-2-biphenylyl-palladium(II)chloride dinorbornylphosphine complex; In tetrahydrofuran; 1,4-dioxane; n-heptane; ethylbenzene; water;