4-Bromo-2-methyl-1-phenylsulfonyl-7-azaindole

Base Information

• Chemical Name: 4-Bromo-2-methyl-1-phenylsulfonyl-7-azaindole
• CAS No.: 1014613-05-8
• Molecular Formula: C14H11BrN2O2S
• Molecular Weight: 351.224
• Hs Code.: 2933990090
• Mol file: 1014613-05-8.mol

Synonyms:4-Bromo-2-methyl-1-phenylsulfonyl-7-azaindole;4-BroMo-2-Methyl-1-(benzenesulfonyl)-1H-pyrrolo[2,3-b]pyridine;4-BroMo-2-Methyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine;1H-Pyrrolo[2,3-b]pyridine, 4-broMo-2-Methyl-1-(phenylsulfonyl)-;1-(Phenylsulphonyl)-4-broMo-2-Methyl-7-azaindole;1-(benzenesulfonyl)-4-bromo-2-methyl-1H-pyrrolo[2,3-b]pyridine;1-(phenylsulfonyl)-4-bromo-2-methyl-7-azaindole

Chemical Property of 4-Bromo-2-methyl-1-phenylsulfonyl-7-azaindole

Chemical Property:

• PSA: 60.34000
• LogP: 4.42500
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

4-Bromo-2-methyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Bromo-2-methyl-1-phenylsulfonyl-7-azaindole

There total 4 articles about 4-Bromo-2-methyl-1-phenylsulfonyl-7-azaindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

1-(benzenesulfonyl)-4-bromo-1H-pyrrolo[2,3-b]pyridine (889939-25-7) + methyl iodide (74-88-4) → 1-(benzenesulfonyl)-4-bromo-2-methyl-1H-pyrrolo[2,3-b]pyridine (1014613-05-8)

Guidance literature:

1-(benzenesulfonyl)-4-bromo-1H-pyrrolo[2,3-b]pyridine; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 0.5h;

methyl iodide; In tetrahydrofuran; at 0 - 20 ℃;

Reference yield: 80.0%

methyl iodide (74-88-4) → 1-(benzenesulfonyl)-4-bromo-2-methyl-1H-pyrrolo[2,3-b]pyridine (1014613-05-8)

Guidance literature:

1-(benzenesulfonyl)-4-bromo-1H-pyrrolo[2,3-b]pyridine; With lithium diisopropyl amide; In tetrahydrofuran; n-heptane; ethylbenzene; at -35 ℃; for 0.5h;

methyl iodide; In tetrahydrofuran; n-heptane; ethylbenzene; at 20 ℃; for 2h;

Reference yield:

benzenesulfonyl chloride (98-09-9) → 1-(benzenesulfonyl)-4-bromo-2-methyl-1H-pyrrolo[2,3-b]pyridine (1014613-05-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / Inert atmosphere

1.2: 0.5 h / Inert atmosphere; Cooling with ice

2.1: lithium diisopropyl amide / tetrahydrofuran / 0.33 h / -50 °C

2.2: 1.33 h / -50 - -30 °C

2.3: -30 °C

With sodium hydride; lithium diisopropyl amide; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;

upstream raw materials:

methyl iodide

1-(benzenesulfonyl)-4-bromo-1H-pyrrolo[2,3-b]pyridine

benzenesulfonyl chloride

4-bromo-7-azaindole

Downstream raw materials:

{4-[2-methyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]phenyl}amine

1,1-dimethylethyl methyl-{4-[2-methyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]phenyl}carbamate

1,1-dimethylethyl {2-[({5-[2-methyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-2-thienyl}sulfonyl)amino]ethyl}carbamate

4-bromo-2-methyl-1H-pyrrolo[2,3-b]pyridine