1-[(2s)-2-[(4-Chlorobenzyl)oxy]-2-(2,4-Dichlorophenyl)ethyl]-1h-Imidazole

Base Information

Chemical Name:1-[(2s)-2-[(4-Chlorobenzyl)oxy]-2-(2,4-Dichlorophenyl)ethyl]-1h-Imidazole
CAS No.:73094-37-8
Molecular Formula:C18H15 Cl3 N2 O
Molecular Weight:381.689
Hs Code.:
UNII:E3VE9L071S
Metabolomics Workbench ID:150869
Nikkaji Number:J304.062C
Wikidata:Q27096923
Mol file:73094-37-8.mol

Synonyms:(S)-Econazole;(+)-Econazole;1-[(2s)-2-[(4-Chlorobenzyl)oxy]-2-(2,4-Dichlorophenyl)ethyl]-1h-Imidazole;Econazole, (S)-;E3VE9L071S;73094-37-8;1-[(2S)-2-[(4-chlorophenyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]imidazole;1H-Imidazole, 1-((2S)-2-((4-chlorophenyl)methoxy)-2-(2,4-dichlorophenyl)ethyl)-;Econazols;S-Econazole;UNII-E3VE9L071S;BIDD:GT0470;SCHEMBL20482166;CHEBI:82872;ECN;DB07705;Q27096923

Suppliers and Price of 1-[(2s)-2-[(4-Chlorobenzyl)oxy]-2-(2,4-Dichlorophenyl)ethyl]-1h-Imidazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 1-[(2s)-2-[(4-Chlorobenzyl)oxy]-2-(2,4-Dichlorophenyl)ethyl]-1h-Imidazole

Chemical Property:

XLogP3:5.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:6
Exact Mass:380.024996
Heavy Atom Count:24
Complexity:379

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=CC=C1COC(CN2C=CN=C2)C3=C(C=C(C=C3)Cl)Cl)Cl
Isomeric SMILES:C1=CC(=CC=C1CO[C@H](CN2C=CN=C2)C3=C(C=C(C=C3)Cl)Cl)Cl

Technology Process of 1-[(2s)-2-[(4-Chlorobenzyl)oxy]-2-(2,4-Dichlorophenyl)ethyl]-1h-Imidazole

There total 16 articles about 1-[(2s)-2-[(4-Chlorobenzyl)oxy]-2-(2,4-Dichlorophenyl)ethyl]-1h-Imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 27646-28-2
(S)-1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol

: 622-95-7
4-chlorobenzyl bromide

: 73094-37-8
(S)-1-(2-((4-chlorobenzyl)oxy)-2-(2,4-dichlorophenyl)ethyl)-1H-imidazole

Guidance literature:: (S)-1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol; With potassium hydride; In tetrahydrofuran; mineral oil; at -78 ℃; for 2h; Inert atmosphere;

4-chlorobenzyl bromide; With 18-crown-6 ether; In tetrahydrofuran; mineral oil; at 20 ℃;
DOI:10.1021/jo102459w

Reference yield: 62.4%

: 24155-42-8
1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol

: 27220-47-9,68797-30-8,73094-37-8,73094-39-0
econazole

Guidance literature:: 1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol; With sodium hydride; In N,N-dimethyl-formamide; at -5 - 20 ℃; for 1.5h; Inert atmosphere;

4-chlorobenzyl halide; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 1h; Inert atmosphere;
DOI:10.1016/j.bmc.2018.02.014

Reference yield:

: 46503-52-0
1-(2,4-dichlorophenyl)-2-(imidazol-1-yl)ethanone

: 27220-47-9,68797-30-8,73094-37-8,73094-39-0
econazole

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tetrahydroborate / methanol / 20 °C

2: potassium iodide / acetonitrile / Reflux

With sodium tetrahydroborate; potassium iodide; In methanol; acetonitrile;
DOI:10.1039/C6SC05368H