naphthalene-2-sulfonic acid {3-[1,1-bis-(4-methoxy-phenyl)-prop-2-ynyl]-phenyl}-methyl-amide

Base Information

• Chemical Name: naphthalene-2-sulfonic acid {3-[1,1-bis-(4-methoxy-phenyl)-prop-2-ynyl]-phenyl}-methyl-amide
• CAS No.: 358673-10-6
• Molecular Formula: C₃₄H₂₉NO₄S
• Molecular Weight: 547.675
• Mol file: 358673-10-6.mol

Synonyms:naphthalene-2-sulfonic acid {3-[1,1-bis-(4-methoxy-phenyl)-prop-2-ynyl]-phenyl}-methyl-amide

Chemical Property of naphthalene-2-sulfonic acid {3-[1,1-bis-(4-methoxy-phenyl)-prop-2-ynyl]-phenyl}-methyl-amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of naphthalene-2-sulfonic acid {3-[1,1-bis-(4-methoxy-phenyl)-prop-2-ynyl]-phenyl}-methyl-amide

There total 6 articles about naphthalene-2-sulfonic acid {3-[1,1-bis-(4-methoxy-phenyl)-prop-2-ynyl]-phenyl}-methyl-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

naphthalene-2-sulfonic acid {3-[hydroxy-bis-(4-methoxy-phenyl)-methyl]-phenyl}-methyl-amide (358673-08-2) + acetylenemagnesium bromide (4301-14-8) → naphthalene-2-sulfonic acid {3-[1,1-bis-(4-methoxy-phenyl)-prop-2-ynyl]-phenyl}-methyl-amide (358673-10-6)

Guidance literature:

naphthalene-2-sulfonic acid {3-[hydroxy-bis-(4-methoxy-phenyl)-methyl]-phenyl}-methyl-amide; With acetyl chloride; at 20 ℃; for 2h;

acetylenemagnesium bromide; In tetrahydrofuran; benzene; at 20 ℃; for 1.5h; Further stages.;

DOI:10.1021/jo001775t

Reference yield:

3-aminobenzoic acid ethyl ester (582-33-2) → naphthalene-2-sulfonic acid {3-[1,1-bis-(4-methoxy-phenyl)-prop-2-ynyl]-phenyl}-methyl-amide (358673-10-6)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 100 percent / DMAP / pyridine / 18 h / 75 °C

2.1: 75 percent / NaOH / ethanol / 22 h / 60 °C

3.1: 94 percent / n-BuLi / hexane; tetrahydrofuran / -78 - 0 °C

4.1: AcCl / 2 h / 20 °C

4.2: 85 percent / benzene; tetrahydrofuran / 1.5 h / 20 °C

With dmap; sodium hydroxide; n-butyllithium; acetyl chloride; In tetrahydrofuran; pyridine; ethanol; hexane; 4.2: Grignard reaction;

DOI:10.1021/jo001775t

Reference yield:

1-bromo-4-methoxy-benzene (104-92-7) → naphthalene-2-sulfonic acid {3-[1,1-bis-(4-methoxy-phenyl)-prop-2-ynyl]-phenyl}-methyl-amide (358673-10-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 94 percent / n-BuLi / hexane; tetrahydrofuran / -78 - 0 °C

2.1: AcCl / 2 h / 20 °C

2.2: 85 percent / benzene; tetrahydrofuran / 1.5 h / 20 °C

With n-butyllithium; acetyl chloride; In tetrahydrofuran; hexane; 2.2: Grignard reaction;

DOI:10.1021/jo001775t

upstream raw materials:

naphthalene-2-sulfonic acid {3-[hydroxy-bis-(4-methoxy-phenyl)-methyl]-phenyl}-methyl-amide

acetylenemagnesium bromide

3-aminobenzoic acid ethyl ester

1-bromo-4-methoxy-benzene

Downstream raw materials:

N-{2-methoxy-5-[1,6,6-tris-(3-{[(2-dimethylamino-ethyl)-methyl-amino]-methyl}-4-methoxy-phenyl)-1,6-bis-(3-methylamino-phenyl)-hexa-2,4-diynyl]-benzyl}-N,N',N'-trimethyl-ethane-1,2-diamine

C₇₂H₅₆N₂O₁₂S₂

2,2,2-trifluoro-N-methyl-N-(3-{1,1,6,6-tetrakis-(3-formyl-4-methoxy-phenyl)-6-[3-(methyl-trifluoroacetyl-amino)-phenyl]-hexa-2,4-diynyl}-phenyl)-acetamide

2,2,2-trifluoro-N-methyl-N-(3-{1,1,6,6-tetrakis-(4-methoxy-phenyl)-6-[3-(methyl-trifluoroacetyl-amino)-phenyl]-hexa-2,4-diynyl}-phenyl)-acetamide