2-[1-((S)-2-{(1R,3aS,7aR)-4-[2-[(S)-5-(tert-Butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-propyl)-1H-[1,2,3]triazol-4-yl]-propan-2-ol

Base Information

Chemical Name:2-[1-((S)-2-{(1R,3aS,7aR)-4-[2-[(S)-5-(tert-Butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-propyl)-1H-[1,2,3]triazol-4-yl]-propan-2-ol
CAS No.:725227-35-0
Molecular Formula:C₃₃H₅₅N₃O₂Si
Molecular Weight:553.904
Hs Code.:

2-[1-((S)-2-{(1R,3aS,7aR)-4-[2-[(S)-5-(tert-Butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-propyl)-1H-[1,2,3]triazol-4-yl]-propan-2-ol

Synonyms:2-[1-((S)-2-{(1R,3aS,7aR)-4-[2-[(S)-5-(tert-Butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-propyl)-1H-[1,2,3]triazol-4-yl]-propan-2-ol

Suppliers and Price of 2-[1-((S)-2-{(1R,3aS,7aR)-4-[2-[(S)-5-(tert-Butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-propyl)-1H-[1,2,3]triazol-4-yl]-propan-2-ol

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Chemical Property of 2-[1-((S)-2-{(1R,3aS,7aR)-4-[2-[(S)-5-(tert-Butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-propyl)-1H-[1,2,3]triazol-4-yl]-propan-2-ol

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 2-[1-((S)-2-{(1R,3aS,7aR)-4-[2-[(S)-5-(tert-Butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-propyl)-1H-[1,2,3]triazol-4-yl]-propan-2-ol

There total 7 articles about 2-[1-((S)-2-{(1R,3aS,7aR)-4-[2-[(S)-5-(tert-Butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-propyl)-1H-[1,2,3]triazol-4-yl]-propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 100858-27-3
(S)-(Z)-{2-[5-(tert-butyldimethylsiloxy)-2-methylenecyclohexylidene]ethyl}diphenylphosphine oxide

: 725227-34-9
(1R,3aR,7aR)-1-{(S)-2-[4-(1-Hydroxy-1-methyl-ethyl)-[1,2,3]triazol-1-yl]-1-methyl-ethyl}-7a-methyl-octahydro-inden-4-one

: 725227-35-0
2-[1-((S)-2-{(1R,3aS,7aR)-4-[2-[(S)-5-(tert-Butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-propyl)-1H-[1,2,3]triazol-4-yl]-propan-2-ol

Guidance literature:: With n-butyllithium; In tetrahydrofuran; at -78 ℃;
DOI:10.1016/j.tetlet.2004.04.117

Reference yield:

: 17963-41-6
2-methyl-2-<(triethylsilyl)oxy>-3-butyne

: 725227-35-0
2-[1-((S)-2-{(1R,3aS,7aR)-4-[2-[(S)-5-(tert-Butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-propyl)-1H-[1,2,3]triazol-4-yl]-propan-2-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 85 percent / CuSO₄*3H₂O; sodium ascorbate / H₂O; 2-methyl-propan-2-ol

2: 86 percent / HF / acetonitrile / 20 °C

3: 50 percent / pyridinium dichromate / CH₂Cl₂ / 20 °C

4: 50 percent / n-BuLi / tetrahydrofuran / -78 °C

With dipyridinium dichromate; n-butyllithium; hydrogen fluoride; copper(II) sulfate; sodium L-ascorbate; In tetrahydrofuran; dichloromethane; water; acetonitrile; tert-butyl alcohol; 4: Wittig-Horner reaction;
DOI:10.1016/j.tetlet.2004.04.117

Reference yield:

: 66774-80-9,111924-49-3
(S)-2-((3R,3aR,7S,7aR)-octahydro-7-hydroxy-3a-methyl-1H-inden-3-yl)propyl 4-methylbenzenesulfonate

: 725227-35-0
2-[1-((S)-2-{(1R,3aS,7aR)-4-[2-[(S)-5-(tert-Butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-propyl)-1H-[1,2,3]triazol-4-yl]-propan-2-ol

Guidance literature:: Multi-step reaction with 6 steps

1: 99 percent / 2,6-lutidine / CH₂Cl₂ / -10 °C

2: 99 percent / NaN₃ / dimethylformamide / 20 °C

3: 85 percent / CuSO₄*3H₂O; sodium ascorbate / H₂O; 2-methyl-propan-2-ol

4: 86 percent / HF / acetonitrile / 20 °C

5: 50 percent / pyridinium dichromate / CH₂Cl₂ / 20 °C

6: 50 percent / n-BuLi / tetrahydrofuran / -78 °C

With 2,6-dimethylpyridine; dipyridinium dichromate; n-butyllithium; sodium azide; hydrogen fluoride; copper(II) sulfate; sodium L-ascorbate; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol; 6: Wittig-Horner reaction;
DOI:10.1016/j.tetlet.2004.04.117