C₃₅H₃₅ClINO₇

Base Information

• Chemical Name: C₃₅H₃₅ClINO₇
• CAS No.: 800374-67-8
• Molecular Formula: C₃₅H₃₅ClINO₇
• Molecular Weight: 744.023
• Mol file: 800374-67-8.mol

Synonyms:C₃₅H₃₅ClINO₇

Chemical Property of C₃₅H₃₅ClINO₇

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₅H₃₅ClINO₇

There total 10 articles about C₃₅H₃₅ClINO₇ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

C35H36ClNO7 (800374-59-8) → C35H35ClINO7 (800374-67-8)

Guidance literature:

With morpholine; iodine; In toluene; at 50 ℃; for 2h;

DOI:10.1055/s-2004-831314

Reference yield:

3-[3-(tert-butyl-dimethyl-silanyloxy)-2-chloro-4-methoxy-phenyl]-acrylic acid methyl ester → C35H35ClINO7 (800374-67-8)

Guidance literature:

Multi-step reaction with 10 steps

1: H₂ / Pd/C / ethyl acetate / 10 h

2: TBAF / tetrahydrofuran / 0.5 h

3: 55 percent / CsF / dimethylformamide / 10 h / 60 °C

4: 90 percent / p-TsOH / 1 h / 20 °C

5: 89 percent / NaOMe / methanol / 6 h / 20 °C

6: 92 percent / NaN₃; PPh₃; CBr₄ / dimethylformamide / 1 h / 0 °C

7: aq. LiOH / tetrahydrofuran / 10 h / 20 °C

8: EDC; DMAP / CH₂Cl₂ / 20 °C

9: 89 percent / PPh₃ / tetrahydrofuran; H₂O / 9 h / Heating

10: 81 percent / I₂; morpholine / toluene / 2 h / 50 °C

With morpholine; dmap; lithium hydroxide; sodium azide; carbon tetrabromide; tetrabutyl ammonium fluoride; hydrogen; iodine; sodium methylate; toluene-4-sulfonic acid; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triphenylphosphine; cesium fluoride; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; toluene;

DOI:10.1055/s-2004-831314

Reference yield:

3-(2-chloro-3-hydroxy-4-methoxy-phenyl)-propionic acid methyl ester (800374-56-5) → C35H35ClINO7 (800374-67-8)

Guidance literature:

Multi-step reaction with 8 steps

1: 55 percent / CsF / dimethylformamide / 10 h / 60 °C

2: 90 percent / p-TsOH / 1 h / 20 °C

3: 89 percent / NaOMe / methanol / 6 h / 20 °C

4: 92 percent / NaN₃; PPh₃; CBr₄ / dimethylformamide / 1 h / 0 °C

5: aq. LiOH / tetrahydrofuran / 10 h / 20 °C

6: EDC; DMAP / CH₂Cl₂ / 20 °C

7: 89 percent / PPh₃ / tetrahydrofuran; H₂O / 9 h / Heating

8: 81 percent / I₂; morpholine / toluene / 2 h / 50 °C

With morpholine; dmap; lithium hydroxide; sodium azide; carbon tetrabromide; iodine; sodium methylate; toluene-4-sulfonic acid; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triphenylphosphine; cesium fluoride; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;

DOI:10.1055/s-2004-831314

upstream raw materials:

C₃₅H₃₆ClNO₇

3-(2-chloro-3-hydroxy-4-methoxy-phenyl)-propionic acid methyl ester

3-[2-Chloro-3-((R)-1-{(3aS,6aR)-4-[(Z)-5-hydroxy-3-(4-methoxy-benzyloxymethyl)-pent-3-en-1-ynyl]-2,2-dimethyl-6,6a-dihydro-cyclopenta[1,3]dioxol-3a-yl}-prop-2-ynyloxy)-4-methoxy-phenyl]-propionic acid methyl ester

3-[3-((R)-1-{(3aS,6aR)-4-[(Z)-5-Azido-3-(4-methoxy-benzyloxymethyl)-pent-3-en-1-ynyl]-2,2-dimethyl-6,6a-dihydro-cyclopenta[1,3]dioxol-3a-yl}-prop-2-ynyloxy)-2-chloro-4-methoxy-phenyl]-propionic acid methyl ester