ethyl (E)-4-(2,6-bis(tert-butyldimethylsilyloxy)phenyl)-2-methylbut-2-enoate

Base Information

Chemical Name:ethyl (E)-4-(2,6-bis(tert-butyldimethylsilyloxy)phenyl)-2-methylbut-2-enoate
CAS No.:939017-95-5
Molecular Formula:C₂₅H₄₄O₄Si₂
Molecular Weight:464.793
Hs Code.:

Synonyms:ethyl (E)-4-(2,6-bis(tert-butyldimethylsilyloxy)phenyl)-2-methylbut-2-enoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ethyl (E)-4-(2,6-bis(tert-butyldimethylsilyloxy)phenyl)-2-methylbut-2-enoate

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Technology Process of ethyl (E)-4-(2,6-bis(tert-butyldimethylsilyloxy)phenyl)-2-methylbut-2-enoate

There total 5 articles about ethyl (E)-4-(2,6-bis(tert-butyldimethylsilyloxy)phenyl)-2-methylbut-2-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 939017-94-4
2-(2,6-bis(tert-butyldimethylsilyloxy)phenyl)acetaldehyde

: 3699-66-9
ethyl 2-diethoxyphosphorylpropionate

: 939017-95-5
ethyl (E)-4-(2,6-bis(tert-butyldimethylsilyloxy)phenyl)-2-methylbut-2-enoate

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride; In acetonitrile; at 20 ℃; for 18h;
DOI:10.1021/jo062447h

Reference yield:

: 939017-92-2
2-allyl-1,3-bis(methoxymethoxy)benzene

: 939017-95-5
ethyl (E)-4-(2,6-bis(tert-butyldimethylsilyloxy)phenyl)-2-methylbut-2-enoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 2.97 g / aq. HCl / tetrahydrofuran; methanol / 36 h / Heating

2.1: 79 percent / imidazole / acetonitrile / 18 h / 20 °C

3.1: ozone / CH₂Cl₂ / -80 - -70 °C

3.2: 89 percent / acetic acid; zinc / CH₂Cl₂ / 0 °C

4.1: 86 percent / LiCl; DBU / acetonitrile / 18 h / 20 °C

With 1H-imidazole; hydrogenchloride; ozone; 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride; In tetrahydrofuran; methanol; dichloromethane; acetonitrile; 4.1: Horner-Wadsworth-Emmons reaction;
DOI:10.1021/jo062447h

Reference yield:

: 939017-93-3
2-allyl-1,3-bis(tert-butyldimethylsilyloxy)benzene

: 939017-95-5
ethyl (E)-4-(2,6-bis(tert-butyldimethylsilyloxy)phenyl)-2-methylbut-2-enoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: ozone / CH₂Cl₂ / -80 - -70 °C

1.2: 89 percent / acetic acid; zinc / CH₂Cl₂ / 0 °C

2.1: 86 percent / LiCl; DBU / acetonitrile / 18 h / 20 °C

With ozone; 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride; In dichloromethane; acetonitrile; 2.1: Horner-Wadsworth-Emmons reaction;
DOI:10.1021/jo062447h