Technology Process of 6-methylene-7a-phenyltetrahydro-1H-pyrrolo[1,2-c][1,3]oxazol-3-one
There total 7 articles about 6-methylene-7a-phenyltetrahydro-1H-pyrrolo[1,2-c][1,3]oxazol-3-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1: LAH / tetrahydrofuran / 0 - 20 °C
2: TEA / CH2Cl2
With
lithium aluminium tetrahydride; TEA;
In
tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmcl.2007.03.006
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: orthoformic acid triethyl ester / 2 h
2.1: sodium hydroxide / tetra(n-butyl)ammonium hydrogensulfate / dichloromethane; water / 10 h / 20 °C
2.2: 2 h
2.3: pH 8
3.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.83 h / 0 °C / Heating / reflux
4.1: triethylamine / dichloromethane / 48 h / 20 °C
With
sodium hydroxide; lithium aluminium tetrahydride; triethylamine; orthoformic acid triethyl ester;
tetra(n-butyl)ammonium hydrogensulfate;
In
tetrahydrofuran; dichloromethane; water;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydroxide / tetra(n-butyl)ammonium hydrogensulfate / dichloromethane; water / 10 h / 20 °C
1.2: 2 h
1.3: pH 8
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.83 h / 0 °C / Heating / reflux
3.1: triethylamine / dichloromethane / 48 h / 20 °C
With
sodium hydroxide; lithium aluminium tetrahydride; triethylamine;
tetra(n-butyl)ammonium hydrogensulfate;
In
tetrahydrofuran; dichloromethane; water;
