5-{(S)-2-Methyl-1-[(S)-2-(3,3,3-trifluoro-1-isopropyl-2-oxo-propylcarbamoyl)-pyrrolidine-1-carbonyl]-propylcarbamoyl}-isophthalic acid dimethyl ester

Base Information

Chemical Name:5-{(S)-2-Methyl-1-[(S)-2-(3,3,3-trifluoro-1-isopropyl-2-oxo-propylcarbamoyl)-pyrrolidine-1-carbonyl]-propylcarbamoyl}-isophthalic acid dimethyl ester
CAS No.:190387-37-2
Molecular Formula:C₂₇H₃₄F₃N₃O₈
Molecular Weight:585.577
Hs Code.:

5-{(S)-2-Methyl-1-[(S)-2-(3,3,3-trifluoro-1-isopropyl-2-oxo-propylcarbamoyl)-pyrrolidine-1-carbonyl]-propylcarbamoyl}-isophthalic acid dimethyl ester

Synonyms:5-{(S)-2-Methyl-1-[(S)-2-(3,3,3-trifluoro-1-isopropyl-2-oxo-propylcarbamoyl)-pyrrolidine-1-carbonyl]-propylcarbamoyl}-isophthalic acid dimethyl ester

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Chemical Property of 5-{(S)-2-Methyl-1-[(S)-2-(3,3,3-trifluoro-1-isopropyl-2-oxo-propylcarbamoyl)-pyrrolidine-1-carbonyl]-propylcarbamoyl}-isophthalic acid dimethyl ester

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Technology Process of 5-{(S)-2-Methyl-1-[(S)-2-(3,3,3-trifluoro-1-isopropyl-2-oxo-propylcarbamoyl)-pyrrolidine-1-carbonyl]-propylcarbamoyl}-isophthalic acid dimethyl ester

There total 3 articles about 5-{(S)-2-Methyl-1-[(S)-2-(3,3,3-trifluoro-1-isopropyl-2-oxo-propylcarbamoyl)-pyrrolidine-1-carbonyl]-propylcarbamoyl}-isophthalic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 190388-00-2
5-{(S)-2-Methyl-1-[(S)-2-(3,3,3-trifluoro-2-hydroxy-1-isopropyl-propylcarbamoyl)-pyrrolidine-1-carbonyl]-propylcarbamoyl}-isophthalic acid dimethyl ester

: 190387-37-2
5-{(S)-2-Methyl-1-[(S)-2-(3,3,3-trifluoro-1-isopropyl-2-oxo-propylcarbamoyl)-pyrrolidine-1-carbonyl]-propylcarbamoyl}-isophthalic acid dimethyl ester

Guidance literature:: With Dess-Martin periodane; trifluoroacetic acid; In dichloromethane; for 18h; Yield given; Ambient temperature;
DOI:10.1021/jm960819g

Reference yield:

: 38588-64-6
3,5-bis(methoxycarbonyl)benzoic acid

: 190387-37-2
5-{(S)-2-Methyl-1-[(S)-2-(3,3,3-trifluoro-1-isopropyl-2-oxo-propylcarbamoyl)-pyrrolidine-1-carbonyl]-propylcarbamoyl}-isophthalic acid dimethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride, (dimethylamino)pyridine / dimethylformamide / 18 h / Ambient temperature

2: 1,1,1-triacetoxy-1,1-dihydro-1,2-benziodoxol-3(1H)-one, TFA / CH₂Cl₂ / 18 h / Ambient temperature

With dmap; Dess-Martin periodane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm960819g

Reference yield:

: (S)-1-((S)-2-Amino-3-methyl-butyryl)-pyrrolidine-2-carboxylic acid (3,3,3-trifluoro-2-hydroxy-1-isopropyl-propyl)-amide

: 190387-37-2
5-{(S)-2-Methyl-1-[(S)-2-(3,3,3-trifluoro-1-isopropyl-2-oxo-propylcarbamoyl)-pyrrolidine-1-carbonyl]-propylcarbamoyl}-isophthalic acid dimethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride, (dimethylamino)pyridine / dimethylformamide / 18 h / Ambient temperature

2: 1,1,1-triacetoxy-1,1-dihydro-1,2-benziodoxol-3(1H)-one, TFA / CH₂Cl₂ / 18 h / Ambient temperature

With dmap; Dess-Martin periodane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm960819g