(4-{2-[(5-Methylsulfanylcarbonimidoyl-pyridine-2-carbonyl)-amino]-acetyl}-phenoxy)-acetic acid methyl ester

Base Information

• Chemical Name: (4-{2-[(5-Methylsulfanylcarbonimidoyl-pyridine-2-carbonyl)-amino]-acetyl}-phenoxy)-acetic acid methyl ester
• CAS No.: 1026281-70-8
• Molecular Formula: C₁₉H₁₉N₃O₅S
• Molecular Weight: 401.443
• Mol file: 1026281-70-8.mol

Synonyms:(4-{2-[(5-Methylsulfanylcarbonimidoyl-pyridine-2-carbonyl)-amino]-acetyl}-phenoxy)-acetic acid methyl ester

Chemical Property of (4-{2-[(5-Methylsulfanylcarbonimidoyl-pyridine-2-carbonyl)-amino]-acetyl}-phenoxy)-acetic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4-{2-[(5-Methylsulfanylcarbonimidoyl-pyridine-2-carbonyl)-amino]-acetyl}-phenoxy)-acetic acid methyl ester

There total 5 articles about (4-{2-[(5-Methylsulfanylcarbonimidoyl-pyridine-2-carbonyl)-amino]-acetyl}-phenoxy)-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-cyano-pyridine-2-carboxylic acid (53234-55-2) → (4-{2-[(5-Methylsulfanylcarbonimidoyl-pyridine-2-carbonyl)-amino]-acetyl}-phenoxy)-acetic acid methyl ester (1026281-70-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 59 percent / 4-ethylmorpholine, ethyl chloroformate / tetrahydrofuran / 1 h / -5 °C

2: 35 percent / MnO₂ / CHCl₃ / 44 h / Ambient temperature

3: H₂S, triethylamine (TEA) / pyridine / Ambient temperature

4: acetone / 50 °C

With N-ethylmorpholine;; manganese(IV) oxide; hydrogen sulfide; chloroformic acid ethyl ester; triethylamine; In tetrahydrofuran; pyridine; chloroform; acetone;

DOI:10.1021/jm00101a017

Reference yield:

methyl phenoxy>acetate (144411-91-6) → (4-{2-[(5-Methylsulfanylcarbonimidoyl-pyridine-2-carbonyl)-amino]-acetyl}-phenoxy)-acetic acid methyl ester (1026281-70-8)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂S, triethylamine (TEA) / pyridine / Ambient temperature

2: acetone / 50 °C

With hydrogen sulfide; triethylamine; In pyridine; acetone;

DOI:10.1021/jm00101a017

Reference yield:

(R,S)-methyl phenoxy>acetate (144412-34-0) → (4-{2-[(5-Methylsulfanylcarbonimidoyl-pyridine-2-carbonyl)-amino]-acetyl}-phenoxy)-acetic acid methyl ester (1026281-70-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 35 percent / MnO₂ / CHCl₃ / 44 h / Ambient temperature

2: H₂S, triethylamine (TEA) / pyridine / Ambient temperature

3: acetone / 50 °C

With manganese(IV) oxide; hydrogen sulfide; triethylamine; In pyridine; chloroform; acetone;

DOI:10.1021/jm00101a017

upstream raw materials:

(4-{2-[(5-Thiocarbamoyl-pyridine-2-carbonyl)-amino]-acetyl}-phenoxy)-acetic acid methyl ester

methyl iodide

5-cyano-pyridine-2-carboxylic acid

methyl phenoxy>acetate

Downstream raw materials:

(4-{2-[(5-Carbamimidoyl-pyridine-2-carbonyl)-amino]-acetyl}-phenoxy)-acetic acid methyl ester