(R)-6-(4-fluoro-2-methoxyphenyl)-N-{6-methyl-4-[(S-methylsulfonimidoyl)methyl]pyridin-2-yl}pyrimidin-4-amine

Base Information

Chemical Name:(R)-6-(4-fluoro-2-methoxyphenyl)-N-{6-methyl-4-[(S-methylsulfonimidoyl)methyl]pyridin-2-yl}pyrimidin-4-amine
CAS No.:1610462-76-4
Molecular Formula:C₁₉H₂₀FN₅O₂S
Molecular Weight:401.465
Hs Code.:

Synonyms:(R)-6-(4-fluoro-2-methoxyphenyl)-N-{6-methyl-4-[(S-methylsulfonimidoyl)methyl]pyridin-2-yl}pyrimidin-4-amine

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Chemical Property of (R)-6-(4-fluoro-2-methoxyphenyl)-N-{6-methyl-4-[(S-methylsulfonimidoyl)methyl]pyridin-2-yl}pyrimidin-4-amine

Chemical Property:

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Technology Process of (R)-6-(4-fluoro-2-methoxyphenyl)-N-{6-methyl-4-[(S-methylsulfonimidoyl)methyl]pyridin-2-yl}pyrimidin-4-amine

There total 9 articles about (R)-6-(4-fluoro-2-methoxyphenyl)-N-{6-methyl-4-[(S-methylsulfonimidoyl)methyl]pyridin-2-yl}pyrimidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1610462-75-3
(rac)-6-(4-fluoro-2-methoxyphenyl)-N-{6-methyl-4-[(S-methylsulfonimidoyl)methyl]pyridin-2-yl}pyrimidin-4-amine

: 1610462-76-4
(R)-6-(4-fluoro-2-methoxyphenyl)-N-{6-methyl-4-[(S-methylsulfonimidoyl)methyl]pyridin-2-yl}pyrimidin-4-amine

: 1610462-77-5
(S)-6-(4-fluoro-2-methoxyphenyl)-N-{6-methyl-4-[(S-methylsulfonimidoyl)methyl]pyridin-2-yl}pyrimidin-4-amine

Guidance literature:: With chiralpak IA; In tert-butyl methyl ether; dimethyl sulfoxide; diethylamine; N,N-dimethyl-formamide; acetonitrile; Resolution of racemate;

Reference yield:

: 1603923-09-6
C₁₉H₁₉FN₄OS

: 1610462-76-4
(R)-6-(4-fluoro-2-methoxyphenyl)-N-{6-methyl-4-[(S-methylsulfonimidoyl)methyl]pyridin-2-yl}pyrimidin-4-amine

: 1610462-77-5
(S)-6-(4-fluoro-2-methoxyphenyl)-N-{6-methyl-4-[(S-methylsulfonimidoyl)methyl]pyridin-2-yl}pyrimidin-4-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium t-butanolate; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione / tetrahydrofuran / 0.17 h / 10 °C / Inert atmosphere

1.2: 1.25 h / 10 °C / Inert atmosphere

2.1: potassium hydroxide; Oxone; water / methanol / 0.75 h / 20 °C / pH 10 - 11

3.1: chiralpak IA / dimethyl sulfoxide; N,N-dimethyl-formamide; diethylamine; acetonitrile; tert-butyl methyl ether / Resolution of racemate

With Oxone; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; water; potassium hydroxide; sodium t-butanolate; In tetrahydrofuran; methanol; tert-butyl methyl ether; dimethyl sulfoxide; diethylamine; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1610462-86-6
(rac)-2,2,2-trifluoro-N-{[(2-{[6-(4-fluoro-2-methoxyphenyl)pyrimidin-4-yl]amino}-6-methylpyridin-4-yl)methyl](methyl)-λ⁴-sulfanylidene}acetamide

: 1610462-76-4
(R)-6-(4-fluoro-2-methoxyphenyl)-N-{6-methyl-4-[(S-methylsulfonimidoyl)methyl]pyridin-2-yl}pyrimidin-4-amine

: 1610462-77-5
(S)-6-(4-fluoro-2-methoxyphenyl)-N-{6-methyl-4-[(S-methylsulfonimidoyl)methyl]pyridin-2-yl}pyrimidin-4-amine

Guidance literature:: Multi-step reaction with 2 steps

1: potassium hydroxide; Oxone; water / methanol / 0.75 h / 20 °C / pH 10 - 11

2: chiralpak IA / dimethyl sulfoxide; N,N-dimethyl-formamide; diethylamine; acetonitrile; tert-butyl methyl ether / Resolution of racemate

With Oxone; water; potassium hydroxide; In methanol; tert-butyl methyl ether; dimethyl sulfoxide; diethylamine; N,N-dimethyl-formamide; acetonitrile;